系统性免疫炎症指数与前循环内血管内血栓切除术后的功能结果相关,急性缺血性中风
Li Han1, Tao Miao2, Le-Yi Zheng3
1Department of Neurology, Taizhou Hospital of Zhejiang Province, Affiliated to Wenzhou Medical University, Linhai, Zhejiang, China.
Frontiers in neurology
|November 7, 2025
概括
系统性免疫炎症指数 (SII) 的升高与急性缺血性中风患者在内血管血栓切除术 (EVT) 后的不良结果有关. 这种炎症标志物不能预测出血并发症,为患者管理提供了洞察力.
科学领域:
- 神经学 神经学
- 免疫学 免疫学 免疫学
- 血管医学 血管医学
背景情况:
- 对于前部循环急性缺血性中风的内血管血栓切除术 (EVT) 通常会导致患者的治疗结果不佳,即使成功重新道化.
- 系统性免疫炎症指数 (SII) 是一个复合标记,反映系统性炎症反应.
- 了解预测EVT后结果的因素对于改善患者护理至关重要.
研究的目的:
- 调查系统性免疫炎症指数 (SII) 与前部循环中风患者经历EVT的临床结果之间的关联.
- 为了确定SII是否预测EVT后的功能不良结果或症状性内出血 (sICH).
主要方法:
- 741名患者的回顾性分析,他们接受了EVT用于前部循环中风.
- 系统性免疫炎症指数 (SII) 计算为 (血小板数 × 中性粒细胞数) / 淋巴细胞数在手术后24小时内.
- 主要结局:在3个月后,功能结局不佳 (修改的兰金尺度3-6). 安全终点:症状性内出血 (sICH).
- 统计分析包括多变量逻辑回归和立方线分析.
主要成果:
- 较高的SII独立地与3个月的功能性结果差 (OR 1.428,P < 0.001) 相关.
- 与最低三位数 (≤928.25) (OR 1.73,P = 0.005) 相比,SII三位数最高的患者 (>1,809) 的糟糕结局几率明显更高.
- 在SII和症状性内出血之间没有发现显著的关联 (OR1.32,P=0.235).
- 观察到SII和功能性结果差的线性剂量-反应关系.
结论:
- 升高的SII是EVT接受前部循环中风患者功能不良结果的独立预测因素.
- 似乎SII与EVT后症状性出血并发症的风险增加无关.
- 对于在急性缺血性中风中接受EVT的患者来说,SII可以作为一个有价值的预后生物标志物.
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