肯尼亚患有或没有炎症性类风湿性疾病的患者中COVID-19的发病率
Benwillies Onchong'a1,2, Tuulikki Sokka-Isler3,4, Pekka Mäntyselkä1,5
1Institute of Public Health and Clinical Nutrition, Faculty of Health Sciences, University of Eastern Finland, Kuopio, Finland.
Journal of public health in Africa
|November 7, 2025
概括
炎症性类风湿性疾病 (IRD) 在肯尼亚医院队列中没有增加COVID-19风险. 这项研究提供了关于IRD和COVID-19的关键非洲数据,突出了潜在的区域差异.
科学领域:
- 类风湿病学 类风湿病学
- 传染性疾病 传染性疾病
- 公共卫生 公共卫生
背景情况:
- 在非洲人群中,炎症性类风湿性疾病 (IRD) 与COVID-19风险之间的关联存在有限的证据.
- 炎症性类风湿性疾病以前被认为是严重的COVID-19结果的潜在风险因素.
研究的目的:
- 研究肯尼亚内罗毕一家大型公共医院出院的患者中炎症性类风湿性疾病和COVID-19风险之间的关联.
- 为全球了解IRD和COVID-19风险提供有价值的非洲数据.
主要方法:
- 在肯尼亚内罗毕的Mbagathi县医院进行了一项前性队列研究.
- 348名IRD患者和2951名非IRD患者在出院后被跟踪了两年.
- 考克斯比例危险模型被用于评估COVID-19风险,根据基线特征进行调整.
主要成果:
- 该队列包括46.2%的女性. IRD患者年龄较大,更容易饮酒,对COVID-19的疫苗接种较少,BMI较高.
- 两年COVID-19发病率在IRD (每100人年4.5) 和非IRD患者 (每100人年5.0) 之间是相似的.
- 根据年龄和性别调整的COVID-19风险在IRD和非IRD患者之间没有显著差异 (危险比:0.9;95%CI:0.6-1.4).
结论:
- 在这个肯尼亚队列中,炎症性类风湿性疾病与COVID-19的风险增加无关.
- 这些发现表明,IRDs可能不是在这个特定的非洲环境中对COVID-19的显著风险因素.
- 这项研究强调了区域数据在了解疾病关联和为公共卫生战略提供信息方面的重要性.
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