在一个患有囊尿的男性患者中,提奥普罗宁诱导的脏综合征
V Karanfilovski1, A Severova Stojanoska1, V Ristovska1
1University Hospital of Nephrology, Faculty of Medicine, Ss. Cyril and Methodius, Skopje, R. North Macedonia.
Balkan journal of medical genetics : BJMG
|November 7, 2025
概括
治疗严重囊尿 (结石) 的药物蒂奥普罗宁可以引起性综合征. 早期检测和药物戒断对于患者从这种罕见的副作用中恢复至关重要.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學.
- 医学遗传学 医学遗传学
- 药理学 药理学 是一个学科.
背景情况:
- 囊尿是一种罕见的,遗传性代谢障碍,由于氨基酸再吸收缺陷导致结石.
- 蒂奥普罗宁用于严重的囊性尿病例,这些病例对保守的治疗有抗性.
研究的目的:
- 报告性综合征的病例作为蒂奥普罗宁在囊性病患者中罕见的不良反应.
- 强调监测提奥普罗宁诱导的不良事件的重要性.
主要方法:
- 一个18岁男性的病例报告,基因证实了囊尿.
- 由于结石的复发,治疗需要采取保守措施,然后启动提奥普罗宁.
- 在提奥普罗宁治疗期间监测副作用.
主要成果:
- 患者在三个月的tiopronin治疗后出现了性综合征 (蛋白尿,低蛋白血,).
- 停止治疗和支持性护理导致在7天内完全的临床和生化缓解.
结论:
- 提奥普罗宁可以诱导性综合征,这是一个严重的不良反应,需要仔细监测.
- 及时干预,包括停止药物治疗,对于管理提奥普罗宁诱导的性综合征至关重要.
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