在缺血性中风患者中长期的缩血压和心血管风险:基于登记的队列研究
Chunbao Mo1,2, Xia Li1,2, Shuang Wang3
1School of Public Health and Emergency Management, School of Medicine, Southern University of Science and Technology, Shenzhen, China.
Journal of global health
|November 7, 2025
概括
在缺血性中风 (IS) 后维持正常或高正常的缩血压 (SBP) 与降低复发性中风和主要不良心血管事件 (MACE) 的风险有关. 最佳的SBP水平可能会带来更大的健康益处,特别是在45-70岁的患者身上.
科学领域:
- 心脏病学 心脏病学
- 神经学 神经学
- 公共卫生 公共卫生
背景情况:
- 长期压缩性血压 (SBP) 对心血管后果的影响 缺血性中风 (IS) 是不充分研究的.
- 现有的研究主要关注血压波动,而不是持续水平.
研究的目的:
- 研究长期SBP水平与IS患者中复发性中风和主要心血管不良事件 (MACE) 风险之间的关联.
- 确定最佳的SBP轨迹,以改善患者的预后,并量化潜在的健康益处.
主要方法:
- 在深,中国 (2017-2023) 的11357名IS患者进行了回顾性队列研究.
- 基于小组的轨迹模型 (GBTM) 确定了释放后的一年SBP模式.
- 倾向性得分重叠加权考克斯回归分析了36个月的随访期间SBP水平和MACE之间的关联.
主要成果:
- 确定了三种SBP模式:正常 (n=2120),高正常 (n=7949) 和不受控制 (n=1288).
- 与不受控制的SBP相比,正常和高正常的SBP与复发性中风或MACE (HRs 0.68-0.89) 的风险明显较低.
- 45-70岁的正常/高正常SBP患者显示出更大的无事件生存益处的潜力.
结论:
- 退院一年后维持正常或高正常的SBP水平与IS患者心血管事件风险降低有关.
- 达到最佳的SBP可能会带来显著的长期健康益处,特别是在年轻到中年IS幸存者中.
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