穿孔植入物的实体评估:通过不同的制造工艺获得的α-三酸水泥和聚合物
Maria Madalena S Oliveira1, Francisco de Assis Dórea Neto1, Alessandra Estrela-Lima1
1School of Veterinary Medicine and Zootechny, Federal University of Bahia, UFBA, Salvador, Brazil.
概括
这项研究比较了四种合成生物材料用于子缺陷. 3D打印的聚合物和α-TCP水泥都显示出良好的生物相容性和骨整合,用于面重建.
科学领域:
- 生物材料科学 生物材料科学
- 再生医学是一种再生医学.
- 口腔和牙面部外科手术
背景情况:
- 下关键大小的缺陷给重建带来了重大挑战.
- 合成生物材料为骨再生提供了自体移植的有希望的替代品.
- 了解不同生物材料的体内性能对于临床转化至关重要.
研究的目的:
- 进行四种合成生物材料的相对体内评估,这些材料具有不同的吸收概况,用于下缺陷重建.
- 评估双重设置的α-三酸 (α-TCPdp),α-TCPdp与乳酸-co-甘油酸和聚烯共聚合物 (PLGA/PI),烯 (ABS) 和聚胺 (PA) 的生物相容性,骨融合和骨新形成能力.
主要方法:
- 用一个临界大小的下缺陷子模型与四个实验组 (每组n=10个缺陷) 进行了实验.
- 30,60和120天的评估包括临床,放射,组织病理和扫描电子显微镜 (SEM) 分析.
- 一个适应的脱协议增强了SEM分析,用于详细的骨植入物接触评估.
主要成果:
- 所有测试的生物材料都显示出出色的生物相容性,骨整合性,没有任何不良组织反应.
- 与基于α-TCP的水泥相比,乙烯乙烯 (ABS) 和聚胺 (PA) 的早期骨新形成显著增加.
- 阿尔法三酸 (α-TCPdp) 和α-TCPdp + PLGA/PI通过降解和爬行替代进行了逐渐的骨替代.
- 添加PLGA/PI调节了炎症反应,但没有阻碍骨质导电性.
- 对于所有材料,SEM证实了持续的骨生长和亲密的骨植入物接触.
结论:
- 可吸收 (基于α-TCP) 和不可吸收 (3D打印聚合物) 生物材料都显示出 mandibular重建的潜力.
- 3D打印的聚合物 (ABS,PA) 促进更快的早期骨形成,而α-TCP水泥则支持逐渐的骨替换.
- α-TCPdp与PLGA/PI的结合提供了一个调节的炎症反应.
- 这些发现支持使用定制合成生物材料进行面重建.
相关概念视频
Porosity and Absorption of Aggregate
Aggregates contain pores of varying sizes; while some are completely enclosed within the particles, others open onto the surface, allowing water to penetrate. The porosity of aggregates is a major factor contributing to the overall porosity of concrete, given that aggregates constitute about three-quarters of concrete's volume.
When all pores in an aggregate are filled with water, the aggregate is considered saturated and surface-dry. If left in dry air, water will evaporate until the aggregate...
When all pores in an aggregate are filled with water, the aggregate is considered saturated and surface-dry. If left in dry air, water will evaporate until the aggregate...
Testing Water Quality
When the quality of water for concrete preparation is uncertain, its impact on the setting time of cement and compressive strength of mortar is assessed by comparison with de-ionized or distilled water benchmarks. American Society for Testing and Materials (ASTM) C1602 requires the setting times to be within 90 minutes of the control, British Standard (BS) 3146:1980 allows a 30-minute variance in the initial setting, while British Standards European Norm (BS EN) 1008 specifies initial setting...
Porosity in Cement Paste
The porosity of concrete is a measure of the void spaces within its structure. These spaces impact its strength and durability significantly. When water and cement interact, a chemical reaction called hydration creates a semi-solid paste. This paste includes combined water, making up approximately 23% of the cement's dry mass, and gel water, which fills minuscule voids known as gel pores, accounting for about 28% of the cement gel volume.
The balance of water to cement in the mix is critical—it...
The balance of water to cement in the mix is critical—it...
Pore Size Distribution
In concrete, the pore size distribution significantly influences the material's properties. Capillary pores, markedly larger than gel pores, form a vast network within partially hydrated cement paste, reducing the concrete's strength and increasing its permeability. This heightened permeability leads to a greater risk of damage from environmental factors like freeze-thaw cycles and chemical attacks, with the extent of vulnerability also being tied to the water-to-cement ratio.
Adequate...
Adequate...
Preplaced Aggregate Concrete
Preplaced aggregate concrete is ideal for construction environments that are not easily accessible. The process begins by properly wetting the gap-graded coarse aggregates to remove the dirt, then placing it in the form and compacting it. Voids are filled with a mortar mix pumped under pressure through slotted pipes. This mortar typically consists of Portland cement, pozzolan, fine aggregates, water, and a fluidizing aid. The pozzolan helps reduce bleeding and segregation while improving the...
Permeability of Concrete
Permeability in the context of concrete refers to how easily liquids or gases can pass through the material. This quality is crucial for assessing the water-tightness and durability of concrete structures and their resistance to chemical attacks. Concrete permeability can be determined through comparative laboratory tests. These tests typically involve sealing a concrete specimen from the sides, applying water pressure to the top surface with pressure, and measuring the amount of water passing...


