短期极端温度,温度波动,以及动脉瘤下关节出血的风险:一个全国性的案例交叉研究
Xiaoyan Guo1,2, Feng Guo3, Lijia Xuan4
1Department of Neurosurgery, Xuanwu Hospital (X.G., C.H., H.Z., T.Z.).
Stroke
|November 7, 2025
概括
短期的极端温度和每天的温度波动增加了动脉瘤下关节出血 (aSAH) 的风险. 高风险人群,包括老年人和高血压患者,面临更大的风险,需要有针对性的预防策略.
科学领域:
- 神经学 神经学
- 环境健康 环境健康
- 流行病学 流行病学
背景情况:
- 存在不一致的证据,关于环境温度和动脉瘤下arachnoid出血 (aSAH) 发作之间的联系.
- 短期温度变化对aSAH风险的影响在很大程度上仍未被描述.
研究的目的:
- 量化短期极端温度,温度波动和aSAH风险之间的暴露-反应关系.
- 为了研究每日平均温度,每日温度范围和每日温度变化对aSAH发病率的影响.
主要方法:
- 使用来自中国33家三级医院的多中心注册表数据库,采用了时间分层的案例交叉研究设计.
- 来自6004个aSAH病例 (2017年5月至2022年12月) 的数据使用有条件逻辑回归与分布式滞后非线性模型进行了分析.
- 暴露评估包括短期极端温度和温度波动 (延迟长达6天),以及它们与aSAH发病的关联.
主要成果:
- 较高或较低的每日平均环境温度,更广泛的日间温度范围和更大的每日温度变化与增加的aSAH风险有显著的关联.
- 这些关联在暴露后持续了长达3天.
- 高血压,年收入低,年龄较大 (≥65岁) 和居住在中国北部被确定为风险因素,特别是在极端温度条件下.
结论:
- 短期极端温度和温度波动与较高的aSAH发病风险有关.
- 高风险人群,包括老年人和患有高血压等先前存在的疾病的人群,风险增加.
- 调查结果强调需要制定定制的公共卫生干预措施和预防策略,以减轻与温度变化相关的aSAH风险.
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