相关实验视频
Updated: Jan 12, 2026
09:48
Monitoring of Nanodrug Accumulation in Murine Breast Cancer Metastases
Published on: August 23, 2024
720
瘤微环境驱动瘤学中MXenes的生物学和治疗潜力
Oksana Sulaieva1,2,3, Nazarii Kobyliak1,3,4, Ihor Panko1,5
1Medical Laboratory CSD, Kyiv 03022, Ukraine.
ACS applied bio materials
|November 7, 2025
概括
二维MXenes显示了精确瘤学的前景,提供直接的瘤切除和免疫微环境调制. 这些纳米材料通过光热效应和pH响应药物递送,使得向癌症纳米异能物成为可能.
科学领域:
- 材料科学 材料科学 材料科学
- 在瘤学瘤学.
- 纳米技术纳米技术
背景情况:
- 二维 (2D) 纳米材料,特别是MXenes,正在成为精密瘤学的强大工具.
- MXenes具有独特的特性,如高表面积,可调化学和高效的光热转换,使它们适合癌症纳米.
研究的目的:
- 本综述探讨了MXenes在癌症治疗中的治疗应用.
- 专注于MXenes在直接瘤切除和调节瘤免疫微环境 (TIME) 中的双重作用.
主要方法:
- 讨论MXenes的作用机制,包括活性氧物种 (ROS) 介导的细胞毒性和光热加热.
- 分析MXenes对免疫细胞功能和瘤免疫相互作用的影响,参考单细胞测序和免疫分析研究.
- 探索MXenes在酸性瘤微环境中的pH响应药物递送能力.
主要成果:
- MXenes表现出直接的抗癌效应,并调节TIME,影响免疫介导的瘤细胞死亡.
- 它们在酸性瘤环境中的选择性反应性支持pH响应药物递送.
- 讨论了将基于MXene的光热疗法与化疗,向药物和免疫疗法相结合的协同策略.
结论:
- MXenes为开发先进的癌症纳米医学平台提供了显著的潜力.
- 对瘤生物学,代谢重编程和 TIME 动态的综合理解对于推进基于 MXene 的疗法至关重要.
- 这种多学科的方法是创建安全,选择性和个性化的癌症治疗的关键.
相关概念视频
02:17The Tumor Microenvironment
7.6K
Every normal cell or tissue is embedded in a complex local environment called stroma, consisting of different cell types, a basal membrane, and blood vessels. As normal cells mutate and develop into cancer cells, their local environment also changes to allow cancer progression. The tumor microenvironment (TME) consists of a complex cellular matrix of stromal cells and the developing tumor. The cross-talk between cancer cells and surrounding stromal cells is critical to disrupt normal tissue...
7.6K
02:57Targeted Cancer Therapies
8.6K
The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
There are several types of targeted therapies against...
8.6K
02:38Mitogens and the Cell Cycle
7.7K
Mitogens and their receptors play a crucial role in controlling the progression of the cell cycle. However, the loss of mitogenic control over cell division leads to tumor formation. Therefore, mitogens and mitogen receptors play an important role in cancer research. For instance, the epidermal growth factor (EGF) - a type of mitogen and its transmembrane receptor (EGFR), decides the fate of the cell's proliferation. When EGF binds to EGFR, a member of the ErbB family of tyrosine kinase...
7.7K
01:15Drugs that Stabilize Microtubules
2.6K
Microtubules are dynamic structures that undergo cycles of catastrophe and rescue. The microtubules play a central role in cell division by forming the spindle apparatus for segregating the chromosomes. This makes them ideal targets for regulating dividing cells in tumors and malignant cancer cells. Microtubule stabilizing drugs help stabilize the microtubule formation and promote its polymerization. Paclitaxel was the first microtubule stabilizing agent used as anticancer drug in chemotherapy...
2.6K
01:10Drugs that Destabilize Microtubules
3.6K
Microtubules are dynamic structures and can be regulated by microtubule targeting agents (MTAs). Microtubule destabilizing drugs are a class of MTAs that destabilize and prevent microtubules' polymerization. Both natural and synthetic chemicals can be found under this class of drugs. Vincristine and vinblastine, two vinca alkaloids, and colchicine were among the first to be discovered. These drugs can affect cells in various ways, either by inducing a change in cell morphology, preventing...
3.6K