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Updated: Jan 12, 2026

A Kinetic Fluorescence-based Ca2+ Mobilization Assay to Identify G Protein-coupled Receptor Agonists, Antagonists, and Allosteric Modulators
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针对癌症免疫治疗的cGAS-STING途径:从小分子激动剂到先进的纳米材料

Zhibin Guo1, Tingting Liu1, Qichao Gao1

  • 1State Key Laboratory of Advanced Separation Membrane Materials, School of Chemistry & School of Chemical Engineering and Technology & School of Material Science and Engineering, Tiangong University, Tianjin 300387, P. R. China.

Molecular pharmaceutics
|November 7, 2025
PubMed
概括

用小分子和纳米材料准干扰素基因 (cGAS-STING) 循环GMP-AMP合成酶刺激器通路,对癌症免疫疗法显示出希望. 这些策略旨在通过增强免疫反应,将冷瘤转化为热瘤.

关键词:
刺痛的激动剂是刺痛的激动剂cGAS-STING 的使用情况.循环二核化物 (CDN) 的使用.免疫疗法 免疫疗法纳米载体的纳米载体有针对性的治疗.

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