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代谢功能障碍相关的肝病的主要人体组织模型 - - 为了简化药物发现,使用患者衍生的试验

Sonia Youhanna^1,2,3, Nayere Taebnia^1,2, Yingxin Liang^1,4

¹Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, 17165, Sweden.

Advanced biology

|November 7, 2025

概括

基于人类的新模型提供了更好的方法来研究与代谢功能障碍相关的脂肪性肝病 (MASLD) 和其进展到与代谢功能障碍相关的脂肪性肝炎 (MASH),有助于药物开发.

科学领域:

肝病学和翻译医学
生物医学工程生物医学工程
药物发现药物发现药物发现

背景情况:

与代谢功能障碍相关的脂肪性肝病 (MASLD) 和其渐进的形式,与代谢功能障碍相关的脂肪性肝炎 (MASH),在全球范围内正在增加.
目前的临床前模型难以完全复制人类的MASLD复杂性,阻碍了治疗的发展.
对MASLD和MASH的有效治疗方法有限,强调需要更好的研究工具.

研究的目的:

审查用于MASLD和MASH研究的新兴基于人类的体外和体外平台.
评估这些平台在建模疾病阶段和特征方面的实用性.
评估它们在药物查和推进MASH治疗方面的潜力.

主要方法:

基于人类的模型的全面审查:二维培养,有机体,三维球体,肝脏切片,微生理系统和生物打印结构.
评估模拟营养和遗传因素,肝细胞多样性和疾病进展的模型.
对MASLD和MASH在药物发现中的模型应用进行分析.

主要成果:

基于人类的模型在复制关键的MASLD/MASH特征方面表现有希望,包括代谢功能障碍,免疫激活和纤维化.
这些平台有助于研究患者特异性倾向和复杂的肝细胞相互作用.
在药物发现中的成功应用突显了这些先进模型的潜力.

结论:

与传统方法相比,新兴的人类平台为MASLD和MASH研究提供了优越的临床前模型.
这些先进的模型对于了解疾病病理生理学和加速开发有效的MASH疗法至关重要.
完善这些以人为中心的模型将弥合MASH药物开发中的翻译差距.

关键词:

马什 (MASH) 是一个非常重要的产品.马斯尔德马斯尔德是什么意思微生理系统的微生理系统有机生物有机物这是患者衍生型的.球形状的球形体是指球形状的球体.

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