在非酒精性脂肪性肝病 (NAFLD) 中的Endocan:系统性审查和元分析
Amir Hossein Behnoush1,2, Amirmohammad Khalaji1,2, Elaheh Karimi1
1School of Medicine, Tehran University of Medical Sciences, Tehran, Iran.
Biomarkers in medicine
|November 7, 2025
概括
在非酒精性脂肪肝 (NAFLD) 患者和健康个体之间,血清内分泌水平没有显著差异. 然而,内分泌干细胞
科学领域:
- 肝病学 肝病学是一种肝病学.
- 心血管研究研究心血管研究
- 生物标志物发现发现
背景情况:
- 非酒精性脂肪性肝病 (NAFLD) 很普遍,并与代谢综合征相关.
- 内皮功能障碍在NAFLD的进展中起着至关重要的作用.
- 内皮损伤的标志物Endocan在NAFLD患者中进行了研究.
研究的目的:
- 系统地评估内分泌在非酒精性脂肪肝疾病中的作用.
- 为了比较NAFLD患者和健康对照者的血清内分泌水平.
- 评估内分泌在NAFLD的诊断准确性和临床相关性.
主要方法:
- 在PubMed,Scopus,Embase和Web of Science进行了全面的文献搜索.
- 包括测量NAFLD患者和对照者的血清内分泌细胞水平的研究.
- 进行了随机效应元分析,以确定标准化平均差异 (SMD) 和95%置信区间 (CI).
主要成果:
- 包含1045名参与者的10项研究被纳入了元分析.
- 在NAFLD患者和对照人群之间,血清内分泌水平没有显著差异 (SMD 0.03,95% CI -0.59至0.65,p=0.931).
- 在NAFLD患者中,NAFLD的诊断准确性各不相同 (AUC 0.647-0.867),内分泌与内皮功能障碍,动脉样硬化和冠状动脉疾病有关.
结论:
- 在NAFLD患者和对照人群中,血清内分泌水平没有显著差异.
- 恩多坎与内皮功能障碍和疾病预后的关联表明,在NAFLD中具有潜在的临床相关性.
- 需要进行更大规模的前性研究,以进一步阐明内分泌在NAFLD中的作用及其临床影响.
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