在没有中风的心房的灰色物质体积异常与或没有轻度认知障碍
Hongzhu Liu1, Tong Li2, Lin Li3
1School of Medical Imaging, Binzhou Medical University, 264003 Yantai, Shandong, China.
Journal of integrative neuroscience
|November 7, 2025
概括
没有中风的心房动 (AF) 患者表现出大脑灰色质 (GM) 损失,特别是在近海马环 (PHG),与轻度认知障碍 (MCI) 相关. 这些结构变化可能预测AF的认知衰退.
科学领域:
- 神经成像是一种神经成像.
- 神经学 神经学
- 认知科学 认知科学
背景情况:
- 心房动 (AF) 与轻度认知障碍 (MCI) 的风险增加有关.
- 在没有中风的AF患者的认知衰退背后的机制尚未完全理解.
- 灰色物质 (GM) 体积变化被调查为潜在的指标.
研究的目的:
- 在非中风患者中研究与认知相关的转基因体积变化.
- 为了比较MCI的AF患者 (AF-MCI),正常认知的AF患者 (AF-NC) 和健康的对照患者 (HCs) 的GM体积.
- 确定与AF认知状态相关的大脑区域.
主要方法:
- 基于voxel的形态测量 (VBM) 分析3D-T1权重的MRI扫描.
- 研究包括40名AF-MCI,40名AF-NC和40名HC,所有人都没有中风.
- 使用VBM评估转基因缩.
主要成果:
- 在没有中风的AF个体中观察到广泛的GM缩,无论认知状态如何.
- 与AF-NC和HC相比,AF-MCI组的转基因损失更为明显.
- 在AF-MCI中,叶,副海马回环 (PHG),小脑和额叶显著减少了GM. 左PHG和右下垂体叶片显示AF-MCI与AF-NC的显著减少.
结论:
- 在没有中风的AF个体中,PHG退化与MCI的概率增加有关.
- 在这个人群中,结构性大脑变化与从正常认知过渡到MCI有关.
- 研究结果表明,有针对性的干预措施的潜力,重点关注结构性变化,以减缓无中风的AF患者的认知衰退.
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