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Updated: Jan 12, 2026

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在小鼠坐骨神经损伤模型中,ROCK抑制通过PI3K/Akt/GSK3β促进轴突和髓再生

Shuang Dou1, Zhijun Li2, Boyao Zheng1

  • 1Institute of clinical applied anatomy, Fujian Key Laboratory of brain aging and neurodegenerative diseases, School of basic medical sciences, Fujian medical university, Fuzhou, Fujian 350122, P.R. China.

International journal of molecular medicine
|November 7, 2025
PubMed
概括

使用ROCK抑制剂向ROCK/PI3K/Akt/GSK3β通路,可促进周围神经的再生和受伤后的功能恢复. 这种途径调节增强了轴突的修复和复髓化,为神经损伤提供了治疗潜力.

关键词:
在ROCK/PI3K/Akt/GSK3β中.轴突再生的重生作用增长 增长 圆 圆 增长 圆周围神经受伤的情况复黄化是复黄化的一种.

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Neurogenesis and Regeneration of Nervous Tissue01:15

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In the CNS, neurogenesis, the birth of new neurons from stem cells, is limited to the hippocampus in adults. In other regions of the brain and spinal cord, neurogenesis is almost non-existent due to inhibitory influences from neuroglia, especially oligodendrocytes, and the absence of growth-stimulating cues. The myelin produced by oligodendrocytes in the CNS inhibits neuronal regeneration. Furthermore, astrocytes proliferate rapidly after neuronal damage, forming scar tissue that physically...
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