75岁的75岁男子与视体瘤引力相关的甲斐丁尼布相关的视网膜下液体
Ophthalmic surgery, lasers & imaging retina
|November 7, 2025
概括
纤维细胞生长因子受体 (FGFR) 抑制剂,如erdafitinib,可以导致下液 (SRF). 已经存在的玻璃瘤引力 (VMT) 可能会增加这种风险,但停止药物可以解决SRF并改善视力.
科学领域:
- 眼科医生 眼科 眼科
- 在瘤学瘤学.
- 药理学 药理学是指药理学的学科.
背景情况:
- 纤维细胞生长因子受体 (FGFR) 抑制剂是重要的癌症疗法.
- 眼部副作用,特别是下液 (SRF),是FGFR抑制剂的常见症状.
- 玻璃瘤引力 (VMT) 是药物诱导的SRF的潜在风险因素.
研究的目的:
- 调查FGFR抑制剂erdafitinib与SRF发展之间的联系.
- 评估基线VMT在药物诱导的SRF中的作用.
- 报告在接受erdafitinib治疗的患者中SRF的临床过程和管理.
主要方法:
- 一个75岁的男性膀癌患者的病例报告.
- 眼科检查,光学连贯断层扫描 (OCT) 和光素血管扫描 (FA) 的分析.
- 在开始,停止和恢复 erdafitinib后监测SRF和视力敏度.
主要成果:
- 患者在开始服用erdafitinib一个月后出现双边SRF和视力下降.
- 停止治疗herdafitinib导致逐渐的SRF解析和视力敏度的改善.
- 海外国家和地区证实了完整的SRF解决方案,随访时稳定的VMT.
结论:
- 埃尔达菲提尼布可以诱导SRF,特别是在患有像VMT这样的视网膜疾病的患者中.
- 早期识别和戒毒对于预防视力丧失至关重要.
- 进一步研究FGFR抑制剂诱导的SRF的机制和预防是有必要的.
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