病毒相关的肺阿斯伯吉洛症:在呼吸道感染中日益成为一个挑战
Amina Pervaiz1, Ayman O Soubani1
1Division of Pulmonary, Critical Care, and Sleep Medicine, Wayne State University School of Medicine, Detroit, MI, USA.
The American journal of the medical sciences
|November 7, 2025
概括
侵入性阿斯伯吉洛症 (IA),特别是像IAPA和CAPA这样的病毒相关性肺阿斯伯吉洛症 (VAPA),具有很高的死亡风险. 早期诊断和治疗对于严重流感和COVID-19患者至关重要.
科学领域:
- 菌类学 菌类学是指菌类学.
- 传染性疾病 传染性疾病
- 关键护理医学 关键护理医学
背景情况:
- 侵入性阿斯伯吉洛症 (IA) 是一种严重的真菌感染,通常是由Aspergillus fumigatus引起的,越来越多地涉及耐药菌株.
- 艾滋病毒主要影响免疫功能低下的患者,但现在包括那些患有严重病毒感染的患者,如流感和COVID-19.
- 病毒相关的肺阿斯伯吉洛症 (VAPA),包括流感相关的肺阿斯伯吉洛症 (IAPA) 和COVID-19相关的肺阿斯伯吉洛症 (CAPA),在重症监护室越来越令人担忧.
研究的目的:
- 审查IAPA和CAPA的病理生理学,临床特征,诊断方法和治疗策略.
- 确定当前的知识差距,并提出关于VAPA的未来研究方向.
主要方法:
- 关于侵入性阿斯伯吉洛症,IAPA和CAPA的现有文献的综述.
- 诊断方法的分析,包括支气管支气管洗,银河测试,阿斯伯吉路斯PCR和支气管镜检查.
- 讨论当前的治疗指导方针,包括醇抗真菌剂和脂质体安福特 B.
主要成果:
- 当适当诊断时,VAPA会影响10-20%的严重流感或COVID-19患者.
- 关键的诊断工具有助于识别严重病患者的真菌感染.
- 尽管接受治疗,但IAPA和CAPA与高死亡率相关,超过50%.
结论:
- 由于IAPA和CAPA具有不良预后,因此构成重大威胁,需要改进诊断和治疗策略.
- 进一步的研究是必要的,以解决了解和管理VAPA的知识差距.
- 多学科方法对于优化VAPA病例患者的治疗结果至关重要.
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