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Updated: Jan 12, 2026

Identification of Mouse and Human Antibody Repertoires by Next-Generation Sequencing
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Identification of Mouse and Human Antibody Repertoires by Next-Generation Sequencing

Published on: March 15, 2019

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沉重建造者:分析结构空间中的抗体重链高吞吐量谱

Joao D Gervasio1, Alexander Greenshields-Watson2, Nele Quast2

  • 1Oxford Protein Informatics Group, Department of Statistics, University of Oxford, 24-29 St Giles', Oxford OX1 3LB, United Kingdom; Laboratório de Biologia Sintética e Biomimética, Departamento de Bioquímica e Imunologia, Universidade Federal de Minas Gerais, Avenida Presidente Antônio Carlos, 6627, Belo Horizonte 31270-901 Minas Gerais, Brazil; Model-Based Evolutionary Genomics Unit, Okinawa Institute of Science and Technology, 1919-1 Tancha, Onna-son, Kunigami-gun, Okinawa, Japan.

Journal of molecular biology
|November 7, 2025
PubMed
概括

使用深度学习,HeavyBuilder可以快速准确地预测抗体重链结构. 这种工具能够进行大规模的免疫谱系分析,揭示了针对药物发现的抗体结构和功能的新见解.

关键词:
抗体建模 抗体模型抗体谱的抗体谱是什么沉重的链条重量级的链条.

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Antibody Structure01:10

Antibody Structure

Overview
Antibodies, also known as immunoglobulins (Ig), are essential players of the adaptive immune system. These antigen-binding proteins are produced by B cells and make up 20 percent of the total blood plasma by weight. In mammals, antibodies fall into five different classes, which each elicits a different biological response upon antigen binding.
The Y-Shaped Structure of Antibodies Consists of Four Polypeptide Chains
Antibodies consist of four polypeptide chains: two identical heavy...
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Antibody Structure and Classes

Antibodies, also known as immunoglobulins, are produced by B cells in response to foreign substances, such as bacteria and viruses. These proteins are critical for recognizing and neutralizing these substances, protecting the body from potential harm.
The basic structure of an antibody consists of four protein chains: two identical heavy chains and two identical light chains. These chains are held together by disulfide bonds and other non-covalent interactions, forming a Y-shaped structure.
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Diversity of Antigen Receptors

Antigen receptors are essential components of the immune system crucial in defending the body against foreign invaders. These receptors are present on the surface of B and T cells, enabling them to recognize antigens and mount an appropriate immune response.
Before encountering any antigen, lymphocytes express these receptors. On B cells, the antigen receptor is a membrane-bound antibody molecule called BCR; on T cells, it is a T cell receptor or TCR. B and T cell receptors are composed of two...
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