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针对肌肉-大脑轴通过FNDC5 / 素 / BDNF通路来改善中风后的认知

Jiating Wei¹, Yuangui Cai¹, Zimu Jiang¹

¹Department of Neurology, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong 510080, PR China; Guangdong Provincial Key Laboratory of Diagnosis and Treatment of Major Neurological Diseases, Guangzhou, Guangdong 510080, PR China; National Key Clinical Department and Key Discipline of Neurology, Guangzhou, Guangdong 510080, PR China.

Journal of advanced research

|November 7, 2025

概括

脑卒中引起的肌肉缩会破坏肌肉-大脑轴,导致认知障碍. 通过运动或基因疗法提高虹膜素水平显示出治疗中风后认知功能障碍的前景.

科学领域:

神经科学是一个神经科学.
肌肉生理学肌肉生理学
内分泌学在内分泌学.

背景情况:

肌肉-大脑轴,涉及FNDC5 / 伊里辛 / BDNF,对于认知功能至关重要.
脑卒中引起的半性肌肉缩可能会破坏这个轴,导致认知缺陷.

研究的目的:

调查是否与中风相关的肌肉缩会损害FNDC5 / 伊利辛 / BDNF轴.
确定轴在中风后认知障碍 (PSCI) 中的作用.

主要方法:

对中风患者和对照者的横截面研究,评估认知能力,血清虹膜素和肌肉MRI.
在中风模型 (子,老鼠) 中评估肌肉缩,FNDC5 / 伊里辛 / BDNF表达和认知.
使用运动或虹素过度表达来治疗小鼠PSCI的干预研究.

主要成果:

脑卒中患者和动物模型显示显著的肌肉缩和血清虹膜素水平降低.
在缩肌肉中观察到FNDC5 / 伊里辛 / BDNF信号的下调,并与认知能力下降有关.
运动或虹膜素的使用改善了海马BDNF水平和神经发生,减轻了大鼠的PSCI.

结论:

半性肌肉缩通过降低FNDC5 / 氨酸 / BDNF轴的调节,有助于PSCI.
提高虹膜素的含量为中风后认知障碍提供了潜在的治疗策略.

关键词:

运动运动运动.虹膜虹膜是一种虹膜.肌肉缩肌肉缩肌肉缩脑卒中后认知障碍脑卒中后认知障碍

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