在怀孕期间治疗混合ACTH和前素分泌的垂体腺瘤
Astrid Le Rigoleur1, Stefan Matei Constantinescu1, Lina Daoud2
1Department of Endocrinology and Nutrition, Cliniques Universitaires Saint-Luc Brussels, Brussels, Belgium.
Endocrinology, diabetes & metabolism case reports
|November 7, 2025
概括
这项案例研究突出了怀孕期间诊断的一种罕见的混合ACTH和益生素分泌的垂体腺瘤. 在第二个三个月的成功手术管理确保了母亲和胎儿的积极结果.
科学领域:
- 内分泌学 在内分泌学.
- 生殖医学 生殖医学
- 神经外科 神经外科
背景情况:
- 库希氏病 (CD) 和前乳腺瘤在怀孕期间带来了诊断和管理的挑战.
- 混合性垂体腺瘤分泌ACTH和益生菌素 (PRL) 异常罕见,妊娠期间的数据有限.
- 怀孕加剧了库辛综合征,增加了母亲和胎儿的风险.
研究的目的:
- 在怀孕期间报告一种混合ACTH和PRL分泌的垂体腺瘤的独特病例.
- 讨论诊断和治疗方面的挑战和结果.
- 强调及时干预的重要性,以改善胎儿和母亲的结果.
主要方法:
- 一名30岁怀孕妇女的病例报告,患有高血性乳血症的症状,并怀疑患有库辛病.
- 在怀孕16周时进行生化研究,垂体MRI和跨形手术.
- 手术后监测荷尔蒙功能和怀孕过程.
主要成果:
- 确定了一种单一的垂体腺瘤,具有明显的ACTH和PRL分泌细胞群.
- 经过成功的跨形手术使皮质醇过量和高血压正常化,导致皮质醇不足.
- 患者在39周通过剖腹产分娩出了一个健康的婴儿,副腎功能在分娩后12个月完全恢复.
结论:
- 混合ACTH/PRL垂体腺瘤很少见,但即使在怀孕期间也可以控制.
- 在怀孕的第二个三个月内进行透视手术是这种瘤的安全和有效治疗方法.
- 早期诊断和手术干预对于孕妇患有库辛病的孕妇和胎儿的良好结果至关重要.
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