糖尿病自主神经病变,外围神经病变和疼痛神经病变的症状驱动的共存
Johan Røikjer1,2,3,4, Mette Krabsmark Borbjerg5,6, Maria Bitsch Poulsen7
1Steno Diabetes Center North Denmark, Aalborg University Hospital, Aalborg, Denmark. J.roeikjaer@rn.dk.
Acta diabetologica
|November 7, 2025
概括
糖尿病自主神经病变 (DAN) 和糖尿病外围神经病变 (DPN) 经常同时存在. 增加DAN严重程度与较高的DPN和疼痛DPN患病率相关,这表明有共同原因.
科学领域:
- 神经学 神经学
- 内分泌学 在内分泌学.
- 糖尿病学 糖尿病学
背景情况:
- 糖尿病自主神经病变 (DAN) 和糖尿病外围神经病变 (DPN) 是常见的糖尿病并发症.
- DAN和DPN之间的共存和症状驱动的关系尚未完全理解.
研究的目的:
- 调查DAN,DPN和疼痛性DPN的共存情况.
- 探索自主功能障碍的严重程度和外围神经病变症状之间的关系.
主要方法:
- 在丹麦北部地区的糖尿病患者中分发了一份电子调查.
- 经过验证的问卷 (MNSI,COMPASS-31,DN4i) 用于评估DPN,DAN和神经病痛.
- DAN严重程度被分为三个层次:SAD-,SAD+和SAD+++.
主要成果:
- 在患有DAN的个体中观察到DPN的显著流行率 (39.6-44.6%).
- 随着DAN严重程度的上升,DPN和疼痛性DPN的患病率显著增加 (p < 0.01).
- 在自主症状负担 (COMPASS-31) 和外围神经病变严重程度 (MNSI) (p < 0.001) 之间发现了强烈的线性关联.
结论:
- 在糖尿病人群中,DAN,DPN和痛苦的DPN经常共存.
- 增加DAN的严重程度与更高的DPN和神经病痛的患病率和严重程度密切相关.
- 这些发现表明,这些糖尿病并发症的共存背后存在着共同的病理生理机制.
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