生物衰老表型调解肠道微生物群对与年龄相关的黄斑变性亚型进展的影响:通过孟德尔随机化和调解分析的遗传因果关系
Yifan Zhou1, Jiabiao Liu2, Zhenyu Wang3
1Shanghai Tenth People's Hospital, School of Medicine, Tongji University, Shanghai, China.
AMB Express
|November 7, 2025
概括
这项研究揭示了肠道微生物影响与年龄相关的黄斑变性 (AMD) 亚型,地理缩 (GA) 和胆道新血管化 (CNV). 特定的细菌可能会减缓AMD的进展,突出显示视力健康中的肠-视网膜轴.
科学领域:
- 眼科医生 眼科 眼科
- 微生物组研究 微生物组研究
- 遗传学 是一个遗传学.
背景情况:
- 与年龄相关的黄斑变性 (AMD) 逐渐发展成不同的亚型:地理缩 (GA) 和冠状动脉新血管化 (CNV).
- 驱动AMD进展及其亚型的精确机制仍然不完全理解.
- 肠道微生物群在包括眼部疾病在内的全身性疾病中的作用是一个新兴的研究领域.
研究的目的:
- 为了确定与AMD进展相关的因果性肠道微生物群 (GM) 种群.
- 调查转基因,生物衰老表型和AMD亚型之间的联系.
- 在AMD的背景下探索潜在的肠-视网膜轴相互作用.
主要方法:
- 利用遗传预测分析了207个转基因种群,205个功能途径和AMD进展GWAS数据之间的关联.
- 研究了与生物衰老标志物的关系:表观遗传时钟加速,端粒长度,线粒体DNA拷贝数,免疫细胞特征和炎症蛋白质.
- 进行调解分析以阐明将转基因与AMD进展联系起来的特定途径.
主要成果:
- 鉴定出Gammaproteobacteria对CNV和GA都有显著的影响.
- 检测到一个涉及Erysipelotrichaceae的双向肠-视网膜轴.
- 类_Flavonifractor,物种_Ruminococcus_obeum和物种_Streptococcus_thermophilus显示出潜在的减轻AMD的进展.
- 确定了特定的介导途径,包括Ruminococcus obeum通过CD4+T细胞表达与GA的联系以及涉及特定免疫细胞计数的CNV途径.
结论:
- 这项研究提供了新的遗传证据,将肠道微生物组与动态AMD进展联系起来.
- 确定了可能影响AMD亚型 (GA和CNV) 的特定微生物种群和途径.
- 这些发现为未来的实验验证和潜在的针对肠-视网膜轴的临床策略提供了遗传洞察力.
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