MTR和AS3MT变异对抗精神病反应的影响:来自希腊自然主义研究的前性证据
Charikleia Ntenti1, Magdalini Filippiadou2,3, Domniki Loukaki-Gkountara4
1First Laboratory of Pharmacology, School of Medicine, Aristotle University of Thessaloniki, Thessaloniki, 54124, Greece. charnten@auth.gr.
Pharmacological reports : PR
|November 7, 2025
概括
单碳代谢和甲基荷胺途径的遗传变异影响了精神分裂症治疗反应. 像MTR rs1805087和COMT rs4680这样的特定多态性显示出个性化抗精神病治疗的潜力.
科学领域:
- 精神病学和遗传学 精神病学和遗传学
- 药物基因组学 药物基因组学
- 代谢途径 代谢途径
背景情况:
- 精神分裂症会导致严重的全球残疾,而抗精神病治疗的反应也会变化.
- 单碳代谢 (叶酸盐,维生素B12),甲基胺降解和甲基化中的遗传因素可能会影响症状严重程度和治疗结果.
- 了解这些遗传影响对于优化患者护理至关重要.
研究的目的:
- 调查关键代谢途径中常见多态性和精神病患者的基线症状之间的关联.
- 评估这些遗传变异与在自然环境中对抗精神病药物的治疗反应之间的关系.
- 探索个性化抗精神病治疗策略中基因分析的潜力.
主要方法:
- 对163名患有精神分裂症或其他精神疾病的患者进行前性观察性研究.
- 在MTHFR (rs1801133),MTR (rs1805087),MTRR (rs1801394),COMT (rs4680) 和AS3MT (VNTR) 中的基因型常见多态.
- 评估了基线症状和四周治疗反应,使用正负综合征量表和卡尔加里抑郁症量表.
主要成果:
- COMT rs4680 多态性与更高的基线负面症状严重程度和更大的抑郁症状减少相关.
- MTR rs1805087 多态性显著与积极的症状改善有关,特别是具有足够的基线维生素B12水平.
- 在维生素B12水平较低的患者中,AS3MT VNTR显示了名义关联与积极症状改善;MTHFR和MTRR没有显著影响.
结论:
- 在MTR和AS3MT中的多态可能基于维生素B12状态来预测抗精神病反应.
- COMT rs4680与负面症状严重程度和抑郁症状改善有关.
- 研究结果表明,尽管研究的局限性,遗传和代谢分析可能有助于个性化抗精神病治疗.
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