果酸寡糖通过肠-大脑轴恢复高脂肪饮食中断的小鼠在认知功能中的日常波动
Zhenting Zhao1, Yuqi Zhao1, Shengquan Dai1
1College of Food Science and Engineering, Northwest A&F University, Yangling 712100, China.
Journal of agricultural and food chemistry
|November 7, 2025
概括
益生菌果酸寡糖 (FOS) 逆转了小鼠的高脂肪饮食引起的认知缺陷. FOS恢复了大脑基因表达,肠道微生物节奏和短链脂肪酸水平,改善了肠-大脑轴的功能.
科学领域:
- 神经科学是一个神经科学.
- 营养科学 营养科学
- 微生物学 微生物学
背景情况:
- 白天的认知功能对大脑健康和代谢平衡至关重要.
- 高脂肪饮食 (HFD) 破坏了这些日常认知节奏.
- 对于HFD诱导的昼间干扰的营养干预尚未得到充分研究.
研究的目的:
- 为了研究益生菌果糖 (FOS) 在改善HFD诱导的白天认知缺陷方面的疗效.
- 探索FOS对海马神经可塑性和神经炎症的影响.
- 评估FOS对肠道微生物群和肠-大脑轴的日常动态的影响.
主要方法:
- 给小鼠食高脂肪饮食 (HFD),含有或不含有果糖-寡糖 (FOS).
- 用巴恩斯迷宫和新型物体识别测试来评估认知功能.
- 分析了海马基因表达 (神经可塑性,神经炎症),肠道微生物群和微生物代谢物 (SCFA).
主要成果:
- 在HFD养小鼠中,FOS治疗改善了白天认知缺陷.
- 在海马体中,FOS恢复了神经可塑性基因和神经炎症标记物的日间振荡.
- FOS使肠道微生物群的日常模式正常化,提高了肠道屏障的完整性,并重新平衡了短链脂肪酸 (SCFA).
结论:
- 益生菌FOS有效地减轻了HFD引起的白天认知障碍.
- 通过调节肠道微生物群和代谢物日间节律,FOS使肠-脑轴活动正常化.
- FOS代表了一种有希望的微生物向的饮食策略,用于与日间干扰有关的代谢障碍.
相关概念视频
01:19Overview of Carbohydrate Metabolism
Carbohydrate metabolism is a fundamental biochemical process that ensures a constant supply of energy to living cells. The most important carbohydrate is glucose, which can be broken down via glycolysis to enter into the Krebs cycle and eventually lead to the production of ATP through oxidative phosphorylation.
Glucose transport into cells is facilitated by a family of transport proteins called GLUT (Glucose Transporters). GLUT4 is the primary glucose transporter for insulin-stimulated glucose...
Glucose transport into cells is facilitated by a family of transport proteins called GLUT (Glucose Transporters). GLUT4 is the primary glucose transporter for insulin-stimulated glucose...
01:18Dysbiosis of the Gut Microbiota
The human gut microbiome includes a diverse array of microbial species, including beneficial commensals and opportunistic pathogens, which interact to support host health. These microbes contribute to essential functions such as nutrient metabolism, immune system modulation, and maintenance of intestinal barrier integrity. However, disruptions to this equilibrium—referred to as dysbiosis—can have widespread physiological consequences.Dysbiosis is often characterized by reduced microbial...
01:22Gut-Brain Axis
The gut–brain axis is a bidirectional communication system that connects the gastrointestinal tract and the brain. This interaction is mediated through multiple pathways, including the vagus nerve, hormonal signals, immune responses, and chemical messengers produced by gut microbes.Microbial Contributions to Brain FunctionGut microbiota contributes significantly to brain function by producing neuroactive compounds. These include neuroactive compounds that influence neurotransmitters such as...