捐赠者的感染风险分层:意大利国家移植中心的活动
Elena Graziano1, Maddalena Peghin1, Maria Luisa Balsamo1
1Infectious and Tropical Diseases Unit, Department of Medicine and Surgery, University of Insubria, ASST Sette Laghi, Varese, Italy.
概括
传染病第二意见 (IDSO) 评估接受了近95%的器官捐赠者,扩大了捐赠者池. 需要进行进一步的研究,以评估具有增加感染风险的捐赠者对移植接受者的影响.
科学领域:
- 移植手术 移植手术
- 传染性疾病 传染性疾病
- 公共卫生 公共卫生
背景情况:
- 扩大器官捐赠池对于移植至关重要.
- 具有感染风险增加的捐赠者需要仔细评估.
- 意大利国家移植中心 (CNT) 使用专家工作组进行复杂的感染性评估.
研究的目的:
- 描述传染病第二意见 (IDSO) 工作组的活动.
- 分析潜在器官捐献者的感染风险评估.
- 评估IDSO对捐赠池接受度的影响.
主要方法:
- 从2022年6月到2023年10月的IDSO活动的回顾性观察研究.
- 根据CNT协议分类的供体感染风险水平的分析.
- 审查感染问题,风险分类和器官排除原因.
主要成果:
- 对30%的捐赠者 (1246/4153) 进行了IDSO请求.
- 大多数捐赠者具有可接受的感染风险增加 (60.8%);只有5.2%被认为是不可接受的.
- 肺炎,炎症标志物升高和细菌病是常见的传染性问题. 肺是被排斥最多的器官 (18.2%).
结论:
- IDSO的活动促进了近95%的被评估捐赠者的接受.
- 对于大量的捐赠者和接受者,提供了额外的测试和治疗指示.
- 未来的国际研究对于确定从具有增加感染风险的捐赠者接受器官的受体的结果至关重要.
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