在共宿蝙蝠物种中检测和基因表征alphacoronaviruses,肯尼亚东南部
Joseph G Ogola1, Hussein Alburkat2,3, Teemu Smura2
1Department of Medical Microbiology and KAVI Institute of Clinical Research, University of Nairobi, Nairobi, Kenya.
PLoS neglected tropical diseases
|November 7, 2025
概括
在肯尼亚蝙蝠中检测到冠状病毒,自由尾物种的流行率更高. 这些发现凸显了蝙蝠与人类和牲畜共享息地的潜在动物传染风险.
科学领域:
- 兽医病毒学 兽医病毒学
- 动物传染病监测动物传染病监测
- 蝙蝠生态学蝙蝠生态学
背景情况:
- 蝙蝠是许多新出现的动物传染病,包括冠状病毒的存储库.
- 在许多地区,特别是非洲东部,对蝙蝠病原体的研究有限.
- 了解蝙蝠冠状病毒的多样性对于评估动物传染性溢出风险至关重要.
研究的目的:
- 调查来自肯尼亚泰塔山的蝙蝠中冠状病毒的流行率和遗传多样性.
- 为在东非一个偏远地区的持续监控工作做出贡献.
- 评估蝙蝠和其他物种之间传播冠状病毒的潜在风险.
主要方法:
- 2018年5月和2019年3月,从16种蝙蝠物种收集了便和肠道样本.
- 用分子方法确定了冠状病毒RNA的流行率.
- 对依赖RNA的RNA聚合酶和全基因组序列进行了植物遗传学分析.
主要成果:
- 在463个样本中检测到6.5%的总体冠状病毒RNA流行率.
- 阿尔法冠状病毒是唯一发现的属.
- 在Mops condylurus (3.8%) 和Mops pumilus (11.6%) 的自由尾蝙蝠中观察到更高的流行率.
- 遗传学分析显示,阿尔法冠状病毒与其他非洲国家的冠状病毒有密切的关系,与中国和澳大利亚的冠状病毒有更为遥远的关系.
结论:
- 冠状病毒在肯尼亚泰塔山区的蝙蝠群体中传播,某些自由尾蝙蝠物种的特别流行率.
- 检测到的冠状病毒与其他非洲蝙蝠中发现的菌株密切相关,这表明区域传播.
- 这些发现强调了由于共享息地而导致冠状病毒传播到人类和牲畜的可能性,需要进一步调查跨物种传播潜力.
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