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Updated: Jan 12, 2026

A Drosophila In Vivo Injury Model for Studying Neuroregeneration in the Peripheral and Central Nervous System
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轴突局部的prenyl-Cdc42mRNA的KHSRP介导的衰变减缓了神经再生

Matthew D Zdradzinski1, Lauren S Vaughn1, Samaneh Matoo1

  • 1Department of Biological Sciences, University of South Carolina, Columbia, South Carolina, United States of America.

PLoS genetics
|November 7, 2025
PubMed
概括

增长抑制降低了轴突Prenyl-Cdc42mRNA,而KHSRP蛋白结合则降低了它的水平. 削减KHSRP通过增加轴突 Prenyl-CDC42.42,加速神经再生.

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In the CNS, neurogenesis, the birth of new neurons from stem cells, is limited to the hippocampus in adults. In other regions of the brain and spinal cord, neurogenesis is almost non-existent due to inhibitory influences from neuroglia, especially oligodendrocytes, and the absence of growth-stimulating cues. The myelin produced by oligodendrocytes in the CNS inhibits neuronal regeneration. Furthermore, astrocytes proliferate rapidly after neuronal damage, forming scar tissue that physically...
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