工程化益生菌恢复GLP-1信号传输,以改善纤维缺乏症恶化的结肠炎
Leonie Brockmann1,2, Carlotta Ronda1,3, Logan T Schwanz1
1Department of Systems Biology, Vagelos College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA.
Science advances
|November 7, 2025
概括
饮食纤维缺乏会通过破坏葡萄糖类1 (GLP-1) 调节而使结肠炎恶化. 益生菌疗法可以恢复GLP-1水平和肠道健康,即使没有食纤维,为结肠炎提供一种新的治疗方法.
科学领域:
- 胃肠病学 胃肠病学
- 微生物学 微生物学
- 内分泌学 在内分泌学.
背景情况:
- 西方低纤维饮食诱导肠道失调,增加大肠炎的风险.
- 来自纤维发酵的短链脂肪酸 (SCFA) 调节葡萄糖类1 (GLP-1) 的分泌.
- GLP-1调节失调,饮食诱导的失调和结肠炎严重程度之间的直接联系尚未完全理解.
研究的目的:
- 为了研究GLP-1在饮食引起的大肠炎中的作用.
- 为了确定GLP-1通路是否可以独立于食纤维的治疗目标.
- 探索益生菌介导的GLP-1调制作为一种治疗策略.
主要方法:
- 使用纤维缺乏饮食的小鼠中硫酸 (DSS) 诱导大肠炎.
- 评估GLP-1水平,L细胞功能和肠道屏障完整性.
- 使用GLP-1受体激动剂和工程益生菌.
主要成果:
- DSS诱导的大肠炎的严重程度与GLP-1水平的增加相关;GLP-1受体阻塞加剧了损伤.
- 纤维缺乏会损害L细胞功能和GLP-1的释放,增加大肠炎的易感性.
- 在缺乏纤维的小鼠中,GLP-1受体激动剂和益生菌疗法恢复了肠道平衡,并减轻了结肠炎.
结论:
- GLP-1在结肠炎中起着至关重要的保护作用,其失调与纤维缺乏有关.
- 针对GLP-1的治疗策略,例如工程益生菌,可以独立于食纤维摄入量来改善结肠炎.
- 益生菌介导的GLP-1升高提供了一种有前途的方法来维持肠道平衡和治疗大肠炎.
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