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Updated: Jan 12, 2026

A High-performance Liquid Chromatography Measurement of Kynurenine and Kynurenic Acid: Relating Biochemistry to Cognition and Sleep in Rats

A High-performance Liquid Chromatography Measurement of Kynurenine and Kynurenic Acid: Relating Biochemistry to Cognition and Sleep in Rats

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慢性压力和大脑 kynurenine 途径:通过临床前研究的元分析方法来解决未解决的问题,对精神疾病的转化影响

Andrea de Bartolomeis¹, Michele Fornaro², Elena Scopetta²

¹Clinical Section of Psychiatry and Psychology - Department of Neuroscience, Reproductive Sciences and Odontostomatology, University School of Medicine Federico II, Naples, Italy; Laboratory of Molecular and Translational Psychiatry, University School of Medicine of Naples Federico II, Naples, Italy.

European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology

|November 7, 2025

概括

慢性压力 (CS) 在动物中显著改变 kynurenine 途径 (KP),增加神经毒性代谢物并影响大脑功能. 这一元分析揭示了KP.

科学领域:

神经科学是一个神经科学.
生物化学生物化学
精神病学是一个精神病学.

背景情况:

kynurenine 途径 (KP) 涉及炎症和突触可塑性,这些过程对大脑功能至关重要.
慢性压力 (CS) 是精神疾病的重要环境风险因素,但潜在的神经生物学机制,特别是KP变化,仍然不清楚.
了解CS如何影响KP对于阐明与压力相关的精神疾病病理生理学至关重要.

研究的目的:

进行临床前动物研究的第一个全面的元分析,以系统地评估CS对KP的影响.
为了确定如何,在多大程度上,以及在哪些大脑区域中,CS对KP代谢物和酶产生影响.
为了确定神经化学途径最受影响的CS在KP.

主要方法:

通过PubMed/MEDLINE,EMBASE和Scopus确定的临床前动物研究的系统审查和元分析.
包括研究调查KP代谢物和酶作为结果的研究,使用标准化平均差异 (SMD).
使用SYRCLE和CAMARADES工具进行质量和偏差风险评估;PROSPERO注册 (CRD42023459414).

主要成果:

CS显著增加了海马和皮质 kynurenine 度 (SMD > 1.5,p < 0.01) 和 kynurenine/tryptophan 比率.
神经毒性林酸水平增加,而神经保护性KYNA水平在海马和皮质下降.
关键的KP酶 (IDO,TDO,KMO) 的表达和活性升高,表明托代谢向KP转移.

结论:

在动物中,慢性压力通过 kynurenine 途径促进托芬代谢.
观察到的转变,其特点是神经毒性林酸增加和KYNA减少,可能会破坏神经保护并导致兴奋毒性.
这些KP变化为CS相关的精神疾病提供了潜在的治疗点,特别是治疗耐药的疾病.

关键词:

抗精神病药,抗抑郁药,抗精神病药,抗抑郁药.双极性障碍是一种双极性障碍.谷氨酸酸盐的使用方法突触可塑性,金氨酸,金氨酸抗治疗抑郁症的治疗方法治疗耐药的精神分裂症

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