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Updated: Jan 12, 2026

Potentiation of Anticancer Antibody Efficacy by Antineoplastic Drugs: Detection of Antibody-drug Synergism Using the Combination Index Equation
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Potentiation of Anticancer Antibody Efficacy by Antineoplastic Drugs: Detection of Antibody-drug Synergism Using the Combination Index Equation

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对simvastatin和vismodegib之间的药理动力学相互作用的机制性见解:对优化结合治疗在脑髓母细胞瘤中的影响

Chaonan Zheng1, Zining Song1, Xing Zou1

  • 1Jiangsu Key Laboratory of Neuropsychiatric Diseases and Department of Pharmacology, College of Pharmaceutical Sciences, Soochow University, Suzhou, China.

Biochemical and biophysical research communications
|November 7, 2025
PubMed
概括

对心膜母细胞瘤的维斯莫迪吉布和西姆瓦斯塔丁联合治疗可能会减少有毒副作用. 维斯莫迪吉布通过抑制OATP1B1和CYP3A4来增强对simvastatin的暴露,可能降低维斯莫迪吉布剂量并减轻骨毒性.

关键词:
药物相互作用 药物相互作用中枢细胞瘤 (Medulloblastoma) 是一个静静的信号通道.西姆瓦斯塔丁是一种协同作用机制是协同作用的机制.在Vismodegib上可以看到.

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