长期暴露于与交通有关的空气污染与表观遗传衰老加速有关
Yueli Yao1, Kathrin Wolf2, Susanne Breitner1
1Institute of Epidemiology, Helmholtz Zentrum München GmbH, German Research Center for Environmental Health, Neuherberg, Germany; Institute for Medical Information Processing, Biometry, and Epidemiology (IBE), Faculty of Medicine, LMU Munich, Pettenkofer School of Public Health, Munich, Germany.
Environmental research
|November 7, 2025
概括
长期暴露于空气污染会加速表观遗传衰老,特别是在经常吸烟的人中. 这项研究揭示了与交通有关的污染物对生物衰老有负面影响,可能会恶化吸烟.
科学领域:
- 环境健康 环境健康
- 表观遗传学 在表观遗传学中,表观遗传学是指表观遗传学.
- 衰老研究研究 衰老研究
背景情况:
- 表观遗传衰老生物标志物,如DNA甲基化 (DNAm) 年龄,可能会受到空气污染的影响.
- 长线证据将长期空气污染暴露与表观遗传衰老联系在一起是有限的.
- 识别受空气污染衰老影响的脆弱人群至关重要.
研究的目的:
- 调查长期暴露于空气污染和表观遗传衰老生物标志物之间的关联.
- 为了确定子组,如一直吸烟者,谁更容易受到这些影响.
- 探索特定空气污染物对DNA甲基化模式的影响.
主要方法:
- 利用来自德国KORA S4调查 (1999-2014) 的纵向数据,并重复测量DNA甲基化.
- 使用土地利用回归模型估计各种空气污染物 (PM,NO2,NOx,O3) 的年平均度.
- 应用线性混合效应模型来评估空气污染物和DNAm年龄之间的关联,基于DNAm的端粒长度 (DNAmTL),并进行了全表观基因组关联研究 (EWAS).
主要成果:
- 对大多数空气污染物 (除O3) 的暴露增加与加速的DNAmGrimAge和DNAmPhenoAge相关.
- 所有测量的空气污染物都显示出与DNAmTL的负相关性.
- 吸烟者在空气污染物,加速表观遗传衰老 (DNAmHorvathAge,DNAmPhenoAge) 和减少DNAmTL之间表现出更强烈的关联,PM2.5abs显示出最大的影响.
结论:
- 长期暴露于与交通有关的空气污染与表观遗传衰老加速密切相关.
- 经常吸烟者代表了一个脆弱的子群体,他们经历了空气污染加剧的衰老影响.
- 空气污染可能会加剧吸烟对生物衰老的影响.
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