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Updated: Jan 12, 2026

A Guide to Production, Crystallization, and Structure Determination of Human IKK1/α
11:27

A Guide to Production, Crystallization, and Structure Determination of Human IKK1/α

Published on: November 2, 2018

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与免疫缺陷相关的 cis 中的复合异合体 NFKB1 误解变体

Manfred Fliegauf1, Kelly Nitschke2, Pavla Mrovecova1

  • 1Institute for Immunodeficiency (IFI), Center for Chronic Immunodeficiency (CCI), Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany.

Clinical immunology (Orlando, Fla.)
|November 7, 2025
PubMed
概括

在NFKB1基因的致病变体是免疫 (IEI) 的先天性错误的常见原因. 复合异合体NFKB1变体可以通过损害p50蛋白,免疫信号的关键因素,导致严重的免疫缺陷.

关键词:
常见的可变免疫缺陷 (CVID)化合物异性是指化合物的异性.免疫的先天性错误 (IEI)在 NF-kappaB 信号系统中.NFKB1 是一个国家.主要免疫缺陷 (PID) 是一种主要的免疫缺陷.

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