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多重乳头瘤:不典型病变的风险, in situ 癌症和侵入性癌症

A Wahnich¹, N Sritharan², C Gu³

¹Department of Obstetrics and Gynecology and Reproductive Medicine, Paris Saclay University, Jean Verdier Hospital, Bondy, Assistance Publique-Hôpitaux de Paris (AP-HP), France.

Journal of gynecology obstetrics and human reproduction

|November 7, 2025

概括

多重乳腺乳头瘤 (MP) 经常被低估,并与高风险病变有关. 由于相关的非典型病变,癌症风险和频繁复发,建议进行外科切除和每年随访.

科学领域:

乳腺病理学乳腺病理学
手术瘤学手术瘤学
诊断成像诊断成像的使用

背景情况:

乳腺乳头瘤是良性瘤,通常与低估高风险病变有关.
目前的证据有限,防止为多发性乳头瘤 (MP) 提供明确的临床管理指南.

研究的目的:

估计与MP相关的非典型病变 (AL),现位癌 (CIS) 和/或侵入性癌 (IC) 的风险.
在MP患者中识别AL,CIS和/或IC的风险因素.
为了评估MP的复发率.

主要方法:

一个观察性,描述性,多中心研究.
包括在2010年至2022年期间诊断出至少两种同步乳头瘤的患者.
排除了手术前诊断的AL,CIS和IC.

主要成果:

128名患者被诊断患有MP;47.7%被诊断为术后患者.
20.3%的患者患有AL,2.3%患有IC.
微化与AL,CIS和/或IC (OR 3.78) 有意义地相关.
复发发生在21.7%的患者中,其中5.0%被诊断为CIS或IC.

结论:

由于低估风险和与AL,CIS和/或IC相关,MP需要外科切除.
由于复发频繁,建议每年进行临床和放射性随访.

关键词:

高危病变的高风险病变导管内 papiloma 是一个内导管内 papiloma.这种病名为 papilomatosis.低估低估低估低估

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