自闭症谱系障碍的临床前模型:过去,现在和未来
Shubham Dwivedi1, Prabha Rajput2, Ansab Akhtar3
1Department of Pharmaceutical Sciences, School of Health Sciences and Technology, UPES, Dehradun 248007, India.
Neuroscience
|November 7, 2025
概括
本综述探讨了自闭症谱系障碍 (ASD) 的临床前模型,评估它们对理解自闭症的可靠性.
科学领域:
- 神经科学是一个神经科学.
- 发展生物学 发展生物学
- 遗传学 是一个遗传学.
背景情况:
- 自闭症谱系障碍 (ASD) 在儿童中存在神经发育和神经行为方面的挑战.
- 尽管已知的环境和遗传影响,但ASD的确切病因和病理生理学仍然不完全理解.
- 临床前模型对于研究ASD的复杂性至关重要.
研究的目的:
- 审查和编制自闭症谱系障碍 (ASD) 的临床前模型.
- 评估各种动物和体外模型的可靠性,优点和缺点.
- 引导研究人员选择适当的模型来推进ASD研究.
主要方法:
- 对ASD临床前模型的综合文献综述.
- 对动物,非动物和体外模型的分析.
- 基于模型模拟ASD行为和分子特征的能力对模型的评估.
主要成果:
- 动物模型传统上是值得信赖的,但新的非动物和体外模型提供了速度和成本效益.
- 对于复制ASD行为和分子特征的新模型的忠实性存在担忧.
- 有一系列的模型可用,每个模型都有特定的优点和局限性来研究自闭症.
结论:
- 了解各种临床前模型的优缺点对于ASD研究至关重要.
- 选择最合适的模型可以显著提高自闭症研究的翻译价值.
- 本综述提供了帮助研究人员选择自闭症研究最佳模型的见解.
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