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Updated: Jan 12, 2026

Coherent anti-Stokes Raman Scattering CARS Microscopy Visualizes Pharmaceutical Tablets During Dissolution
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通过光学相干断层扫描评估的酸阶段溶解的技术和监管观点 (第二部分:稳定性场景)

Jesús Alberto Afonso Urich1, Raymar Andreina Lara Garcia2, Matthias Wolfgang2

  • 1Research Center Pharmaceutical Engineering GmbH, Inffeldgasse 13, 8010 Graz, Austria; Institute of Process and Particle Engineering, Graz University of Technology, Inffeldgasse 13, 8010 Graz, Austria.

International journal of pharmaceutics
|November 7, 2025
PubMed
概括

光学一致性断层扫描 (OCT) 提供了一种非破坏性的药物稳定性测试方法. 这种技术准确地测量肠道涂层厚度,确保整个保质期的药物保护,并证明与传统溶解测试的等价性.

关键词:
溶解测试是一种溶解测试.肠膜涂层 肠膜涂层 肠膜涂层光学连贯性断层扫描 (OCT)监管合规性符合性 监管合规性稳定性测试 稳定性测试 稳定性测试

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Orally administered drugs primarily enter the systemic circulation via passive diffusion through the intestinal membranes. The drug's absorption is influenced by drug stability in the gastrointestinal GI tract, membrane permeability, the surface area available for absorption, luminal drug concentration, and residence time in the lumen. Drug permeability can be enhanced by adjusting the lipophilicity, polarity, or molecular size of the drug, promoting its passive transport across intestinal...
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