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在人乳头瘤病毒接种疫苗的妇女中对宫癌查频率的受控试验

Mònica Ortega Llobet¹, Penelope Gray¹, Iacopo Baussano²

¹Centre for Cervical Cancer Elimination, Department of Clinical Science, Intervention and Technology, Karolinska Institutet, Stockholm, Sweden.

International journal of cancer

|November 7, 2025

概括

在接种了人类乳头瘤病毒 (HPV) 疫苗的妇女中,宫癌查可能不那么频繁. 降低查强度的结果与高强度查的结果相似,原因是疫苗接种个体的HPV流行率下降.

科学领域:

妇科妇科妇科妇科
在瘤学瘤学.
疫苗学疫苗学疫苗学

背景情况:

在接种了瘤源人乳头瘤病毒 (HPV) 疫苗的个体中,没有评估宫查频率.
接种HPV疫苗正在减少HPV的患病率,这是宫癌的主要危险因素.
了解最佳查策略至关重要,因为疫苗接种会影响与HPV相关的疾病发病率.

研究的目的:

评估在青春期早期接种HPV疫苗的妇女不同宫查频率的有效性.
为了比较HPV疫苗接种妇女的高强度和低强度查臂之间宫癌前体 (HSIL/CIN2+) 的发生率.

主要方法:

一项随机试验 (NCT02149030) 将22岁的接种HPV疫苗的女性 (12-15岁) 分给基于细胞学的高强度 (A1臂) 或低强度 (A2臂) 查.
第三个手臂 (A3手臂) 包括在18岁时接种疫苗的妇女,在低强度查手臂中.
细胞学和HPV发现的患病率在22岁,25岁和28岁被评估. 对CIN2+的危险比率在查臂之间进行了比较.

主要成果:

在28岁时,高强度 (0.70%) 和低强度 (0.66%) 查臂 (HR 0.97;95% CI,0.50-1.88) 中,CIN2+的总体发生率与28岁时相似.
在12-15岁接种疫苗的妇女中,疫苗型HPV (16/18) 患病率在28岁时降低了高达88%,与18岁接种疫苗的妇女相比.
低强度查,即使在6年内没有发现低级异常,也产生了与高强度查相似的结果.

结论:

在接受低强度与高强度宫查的HPV疫苗接种妇女中,高度宫内皮瘤瘤 (CIN2+) 的风险类似.
由于疫苗接种导致瘤性HPV患病率的下降可能是使查强度降低的主要因素.
这些发现表明,在接种HPV疫苗的人群中,宫查频率可以安全地减少.

关键词:

在HPV疫苗接种过程中.有关RCT的RCT是什么宫部查宫部查宫部查

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