器官工程的神经中心
Suradip Das1,2, Wisberty J Gordián-Vélez3,4,5, Jay R Dave3,4
1Center for Brain Injury & Repair, Department of Neurosurgery, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA. suradip@pennmedicine.upenn.edu.
Nature communications
|November 7, 2025
概括
工程人造器官需要整合神经才能正常工作. 本综述探讨了神经输入如何调节器官,并讨论了将内化纳入工程器官的策略,以获得更好的治疗结果.
科学领域:
- 生物医学工程 生物医学工程
- 神经科学是一个神经科学.
- 再生医学是一种再生医学.
背景情况:
- 器官工程正在推进治疗技术.
- 内化对于器官的发育,功能和恒温至关重要.
- 神经网络在工程器官中的整合尚未得到充分探索.
研究的目的:
- 审查神经输入在关键器官调节中的作用.
- 检查器官特定的神经解剖学和将内化纳入工程器官的策略.
- 倡导内化作为下一代人工器官的基本设计元素.
主要方法:
- 关于特定器官神经解剖学的文献综述.
- 对脚手架设计,多细胞培养,神经工程和生物制造等新兴策略的分析.
- 讨论在体外,临床前和临床环境中评估内置的工具.
主要成果:
- 神经输入显著调节关键器官,如胰腺,肝脏,唾液腺和脏.
- 生物材料和生物制造方面的创新为创建功能性神经元-轴突网络提供了潜力.
- 在不同的研究环境中,需要标准化的方法来评估内化.
结论:
- 成功的器官工程必须优先考虑功能内置的整合.
- 未来的人工器官需要一种神经中心的设计方法.
- 需要进一步的研究来弥合神经工程和器官生物制造之间的差距.
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