年龄调节了与压力相关的神经活动和死亡率之间的联系
Nidaa Mikail1,2, Noemi Sablonier1,2, Pimrapat Gebert1,2,3
1Department of Nuclear Medicine, University Hospital Zurich, Zurich, Switzerland.
Nature communications
|November 7, 2025
概括
通过杏仁体代谢测量压力相关的神经活动 (SNA),与死亡率有关. 这种关联在年轻人中最强烈,并且随着年龄的增长而减弱,可能改善风险预测.
科学领域:
- 神经科学是一个神经科学.
- 心脏病学 心脏病学
- 老年学是一门学科.
背景情况:
- 与压力相关的神经活动 (SNA),指的是杏仁体代谢,与死亡率和心血管事件有关.
- 以前的研究表明,SNA与不良健康结果之间存在联系.
研究的目的:
- 确定影响SNA的因素.
- 调查年龄是否改变SNA和全因死亡率之间的关系.
主要方法:
- 使用2-[18F]-2-脱氧-D-葡萄糖正子发射断层扫描 (18F-FDG-PET) 来测量杏仁体代谢 (SNA替代物).
- 在1336名患者中量化SNA,在960名参与者中分析了死亡率关联,在中位数为5年的随访期间.
- 评估人口统计和成像混因素.
主要成果:
- 更高的SNA独立地预测了所有原因死亡率的增加 (HR 1.45,p=0.012).
- SNA与死亡率之间的关联在年轻,更健康的人群中最为明显 (HR 7.86,p<0.001),并且随着年龄的增长而下降.
- 调解分析显示,SNA占年龄与死亡率关系的38.2%.
结论:
- SNA是所有原因死亡率的独立预测因素,在年轻人中效果更强.
- 随着年龄的增长,效应大小的减少表明,SNA在死亡风险中的作用可能会在整个生命周期中发生变化.
- 将SNA纳入风险模型可以提高死亡率预测,特别是识别年轻人可能受益于更密切的监测和预防策略.
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