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Updated: May 4, 2026

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通过单细胞多基因组分析,探讨肝癌的亚克隆异质性

Liwen Zhang1, Dandan Hu2,3, Xing Peng4

  • 1School of Life Sciences, Westlake University, No. 600 Dunyu Road, Hangzhou, 310030, Zhejiang, China.

Scientific reports
|November 7, 2025
PubMed
概括

多结节性肝细胞癌 (HCC) 呈现出比单结节型更大的异质性. DNA甲基化模式,而不是基因表达,更好地跟踪瘤进化,确定GADD45A和SNHG6作为潜在的低甲基化驱动因素.

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Cancer arises from mutations in the critical genes that allow healthy cells to escape cell cycle regulation and acquire the ability to proliferate indefinitely. Though originating from a single mutation event in one of the originator cells, cancer progresses when the mutant cell lines continue to gain more and more mutations, and finally, become malignant. For example, chronic myelogenous leukemia (CML) develops initially as a non-lethal increase in white blood cells, which progressively...
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