成年患者在ECMO期间获得的XIII因子缺乏症:一项前性观察性研究
Matthias Noitz1,2, Dennis Jenner3, Thomas Tschoellitsch4,3
1Department of Anesthesiology and Intensive Care Medicine, Kepler University Hospital GmbH, Johannes Kepler University, Krankenhausstraße 9, 4020 Linz and Altenberger Strasse 69, 4040, Linz, Austria. mnoitz@gmx.at.
Scientific reports
|November 7, 2025
概括
获得的XIII因子 (FXIII) 缺乏症在体外膜氧化 (ECMO) 的成年人中非常常见,影响超过90%的患者. 较低的FXIII活性与血红蛋白和输血相关,但没有预测重大出血事件.
科学领域:
- 血液学 血液学 血液学
- 关键护理医学 关键护理医学
- 心血管外科心血管外科
背景情况:
- 第十三因子 (FXIII) 对于凝块稳定至关重要.
- 在接受体外膜氧化 (ECMO) 的患者中,关于FXIII活性的数据有限.
- 获得的FXIII缺乏症是重症患者的潜在并发症.
研究的目的:
- 为了确定成年ECMO患者获得的FXIII缺乏症的发病率.
- 评估FXIII活性,血红蛋白水平,输血需要和严重出血之间的关系.
- 评估FXIII活动在ECMO期间大出血的预测价值.
主要方法:
- 前性,观察性,单中心研究.
- 包括44名接受ECMO治疗的成年患者.
- 统计分析包括描述性统计,相关性和ROC曲线分析.
主要成果:
- 93.2%的患者患有已获得的FXIII缺乏症 (活性<70%).
- 最小的FXIII活性与较低的血红蛋白和增加的红细胞输血需求相关.
- FXIII活性没有显著预测主要出血事件 (AUC = 0.602).
结论:
- 获得的FXIII缺乏症在成年ECMO患者中非常普遍.
- 较低的FXIII活性与贫血和输血需求有关,但没有严重的出血.
- 需要进一步的研究来确定FXIII监测和替代是否能改善ECMO的结果.
相关概念视频
Pulmonary Embolism II: Diagnostic Studies and Interprofessional Care
293
Diagnosing Pulmonary EmbolismDiagnosing pulmonary embolism (PE) involves clinical assessment and advanced imaging tests. The preferred diagnostic tool is the spiral (helical) CT scan or CT angiography (CTA), which uses intravenous contrast media to visualize the pulmonary vasculature and identify emboli.A ventilation-perfusion (V/Q) scan is an alternative for patients unable to receive contrast media. This scan includes both perfusion and ventilation scanning. Perfusion scanning involves...
293
Pulmonary Embolism III: Nursing Management
343
A pulmonary embolism occurs when a thrombus, amniotic fluid, tumor tissue, fat, or air embolus blocks one or more pulmonary arteries. Effective nursing management and patient education are crucial for improving outcomes and preventing recurrence.Nursing management starts with obtaining a comprehensive patient history, particularly noting any history of deep vein thrombosis (DVT). Assess for clinical manifestations, including dyspnea, chest pain, crackles, heart murmurs, and signs of right-sided...
343
Acute Respiratory Failure-III
749
Hypercapnic respiratory failure, also known as Type 2 or ventilatory respiratory failure, is a severe condition characterized by the body's inability to effectively remove carbon dioxide (CO2) from the bloodstream. It leads to an arterial CO2 pressure (PaCO2) exceeding 45 mmHg and a blood pH above 7.35. This situation indicates that the body's ventilatory demand, or the ventilation needed to maintain normal PaCO2 levels, surpasses its supply or the maximum gas flow achievable without...
749
Venous Thrombosis III: Interprofessional Care
271
Venous thrombosis requires effective prevention and treatment strategies to improve patient outcomes and reduce potential complications.Prevention StrategiesHealthcare providers must prioritize preventing venous thromboembolism (VTE) for all adult patients upon admission. Interventions depend on bleeding and thrombosis risk, medical history, current medications, diagnoses, planned procedures, and patient preferences. Patients on bed rest should change positions every two hours and, if not...
271
Factors Affecting Pulmonary Ventilation
2.8K
Besides the pressure difference between the external environment and the lungs, the airflow rate and ease of pulmonary ventilation are also influenced by three other factors: surface tension of the fluid in the alveoli, compliance of the lungs, and airway resistance.
Alveolar Surface Tension
The alveolar fluid lines the luminal surface of the alveoli and exerts a force called surface tension. This force is caused by the polar water molecules in the liquid being more strongly attracted to each...
Alveolar Surface Tension
The alveolar fluid lines the luminal surface of the alveoli and exerts a force called surface tension. This force is caused by the polar water molecules in the liquid being more strongly attracted to each...
2.8K
Acute Coronary Syndrome III: Diagnostic Studies
200
Diagnosing acute coronary syndrome or ACS begins with a thorough patient history. Notable symptoms include central, crushing chest pain radiating to the left arm, neck, jaw, or back, along with shortness of breath, sweating (diaphoresis), nausea, vomiting, dizziness, and palpitations.It is crucial to note any history of cardiac illnesses and assess risk factors, including age, gender, smoking, hypertension, diabetes, hyperlipidemia, and a sedentary lifestyle.During physical examination, vital...
200


