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网络毒理学,转录学和细胞毒性验证揭示了TDCPP诱导的pterygium机制

Ji Yang¹, Jiajie Li¹, Boyu Liang¹

¹Department of Ophthalmology, The Eye Disease Clinical Medical Research Center of Yunnan Province, the Eye Disease Clinical Medical Center of Yunnan Province, The Second People's Hospital of Yunnan Province, Affiliated Hospital of Yunnan University, Kunming, China.

Scientific reports

|November 7, 2025

概括

1,3-二chloro-2-propyl) 酸盐 (TDCPP) 暴露可能通过增加MMP3表达,促进纤维细胞增殖和细胞外基质重塑来促进体发育. 这项研究突出了TDCPP作为眼睛表面疾病的潜在环境风险因素.

科学领域:

环境健康环境健康
毒理学毒理学毒理学
眼科医生眼科眼科

背景情况:

是与紫外线暴露等环境因素相关的眼睛表面疾病.
在环境和生物样本中发现有机酸盐阻燃剂Tris ((1,3-二二) 酸盐 (TDCPP).
对于TDCPP在pterygium病原发生中的作用尚不清楚.

研究的目的:

为了研究将TDCPP暴露与pterygium发育联系起来的分子机制.
确定TDCPP相关的眼睛表面疾病的潜在治疗点.

主要方法:

综合性方法:网络毒理学,转录组测序,体外细胞毒性检测.
生物信息学分析以确定TDCPP标和与pterygium相关的基因.
权重基因共同表达网络分析 (WGCNA) 和分子对接模拟.
在体外实验中使用人类结膜纤维细胞.

主要成果:

鉴定了TDCPP目标和pterygium基因之间的43个重叠基因.
突出了MMP3作为膜病变发生的中心调节者.
通过分子模拟证实了TDCPP和MMP3之间的稳定相互作用.
低剂量TDCPP上调MMP3,增强纤维细胞增殖;高剂量诱导细胞毒性.

结论:

通过MMP3介导的细胞外基质重塑和纤维细胞增殖,TDCPP促进菌病原性.
MMP3被确定为TDCPP相关的眼睛表面疾病的潜在治疗标.
这项研究提供了关于pterygium的环境病因学的见解.

关键词:

细胞毒性细胞毒性在MMP3中使用MMP3.网络毒理学网络毒理学在Pterygium的基础上.这就是TDCPPPPTDC.文字转录学 (Transcriptomics) 是一个学科.

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