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乐高-3D:使用光板光显微镜对肺转移和血管化的3D成像

Sabrina M Lewis^1,2,3, Jean Berthelet^4,5, Lachlan W Whitehead^1,2

¹Walter and Eliza Hall Institute of Medical Research, Parkville, VIC, Australia.

|November 7, 2025

概括

研究人员开发了一种新方法来追踪转移性乳腺癌中的癌细胞. 多色色转移不太常见,并且偏好在肺部血管附近的位置.

科学领域:

在瘤学瘤学.
细胞生物学细胞生物学
医疗成像医学成像

背景情况:

癌症转移是一个复杂的过程,涉及癌细胞迁移和远处器官的播种.
了解转移性传播的动态,特别是在肺部,对于有效的癌症治疗至关重要.
瘤和肺微环境中的异质性影响了转移性殖民.

研究的目的:

优化一种用于追踪转移性乳腺癌瘤内的癌细胞的方法.
为了研究转移期间癌细胞和肺血管之间的相互作用.
在三维 (3D) 肺组织中分析转移性模式.

主要方法:

使用基于lentiviral的光学条形码 (LeGO) 来追踪癌细胞.
采用光板显微镜,对整体的肺叶进行高分辨率的3D成像.
进行了自发和实验性转移的小鼠模型.

主要成果:

多色转移的频率比单色转移的频率少.
转移,特别是多色转移,更喜欢靠近血管的位置.
证明了在大量组织中分析转移性异质性和动态的可行性.

结论:

开发的3D成像和分析管道为转移性异质性和动态提供了新的见解.
这种方法可以应用于在大量的肺组织中研究治疗反应.
这些发现突显了转移和肺中的血管之间的空间关系.

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