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膜结合的PI3Kα H1047R突变的结构和质效应以及药物发现的机会

Danai Maria Kotzampasi1,2, Zoe Cournia3

  • 1Department of Biology, University of Crete, Heraklion, Greece. dkotzamp@bioacademy.gr.

Communications chemistry
|November 7, 2025
PubMed
概括

在PI3Kα (酸胺3-酶α) 中的H1047R突变稳定了细胞膜上的蛋白质,增强了其活性. 这种突变促进了开放的形状,在蛋白质膜接口提供了新的治疗点.

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