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全基因组测序在转移性结直肠癌中的临床影响

Lidwien P Smabers1,2, Hilde H Nienhuis1,3, Wendy W J de Leng4

  • 1Department of Medical Oncology, University Medical Center Utrecht, Utrecht University, Utrecht, the Netherlands.

Oncogene
|November 7, 2025
PubMed
概括

全基因组测序 (WGS) 识别了转移性结直肠癌 (mCRC) 患者的关键生物标志物,改善了个性化治疗决策. 这种先进的基因组测试显著增加了基于生物标志物的治疗方法的使用,以获得更好的患者结果.

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Genetic polymorphisms in drug targets have emerged as critical determinants of interindividual variability in drug response and toxicity. Pharmacogenomic investigations increasingly focus on identifying these variations to personalize and optimize therapeutic interventions. A drug target may be a receptor, enzyme, or signaling protein involved in pharmacologic responses or disease-related pathways. While early pharmacogenetic studies focused primarily on drug metabolism, current research...