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密度梯度离心特别改善高尿血症的精子运动性:来自子宫内受精周期的证据 - 追溯队列研究

Jinqiang Peng¹, Lingjuan Wu¹, Zhimin Li¹

¹Reproductive Medical Center, Affiliated Hospital of Putian University, 999 Dongzhen East Road, Putian, Fujian, China.

Basic and clinical andrology

|November 7, 2025

概括

密度梯度离心 (DGC) 在患有高尿素血症 (HUA) 的男性中显著改善精子运动性,这种情况会损害精子功能. 然而,这项改善本身并没有增加本研究中的临床怀孕率.

科学领域:

生殖医学生殖医学
安德罗学与人类学
生物化学生物化学

背景情况:

超尿血 (HUA) 通过氧化应激和代谢障碍对精子功能产生负面影响.
男性不孕症是一个重大问题,HUA是一个可识别的贡献因素.
了解与HUA相关的精子功能障碍的干预措施对于生殖健康至关重要.

研究的目的:

评估密度梯度离心 (DGC) 治疗密度梯度离心 (DGC) 治疗与高尿血 (HUA) 相关的精子功能障碍的疗效.
为了比较HUA和没有HUA接受辅助生殖技术的男性之间的精子参数和临床结果.
调查DGC在减轻HUA对精子质量负面影响方面的潜力.

主要方法:

追溯性队列研究,涉及490对夫妇进行首次子宫内授精 (IUI).
根据血清尿酸水平,患者被分为超尿血症 (HUA) 组 (200 个周期) 和对照组 (290 个周期).
在密度梯度离心 (DGC) 处理之前和之后,分析了精子参数,特别是渐进性运动精子 (PR%).

主要成果:

基线逐步运动精子 (PR%) 在HUA组明显低于对照组.
在DGC之后,两组的PR%都超过了90%,在HUA组观察到的增幅明显更大 (ΔPR%).
在HUA和对照组之间的临床怀孕率中没有发现统计学上显著的差异.

结论:

密度梯度离心 (DGC) 证明了在增强高尿血症 (HUA) 患者的精子运动性方面具有特定的益处.
观察到的运动能力的改善可能归因于DGC降低氧化应激和优化精子能量代谢的能力.
虽然DGC改善了HUA患者的精子运动性,但仅仅这种增强不足以显著改善临床怀孕率,这表明需要多因素方法来管理与HUA相关的不孕症.

关键词:

密度梯度离心法离心法密度梯度离心法超性血症 (hyperuricemia) 是一种疾病,在子宫内进行授精.男人不孕不育的情况有反应性氧物种的反应性氧物种.精子运动性精子运动性

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