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心脏手术后的血糖变化和术后死亡率:来自现实世界ICU队列的证据
Fengwei Yao1, Fan Yang2, Xiaolan Chen1
1Department of Gastrointestinal Surgery, Renmin Hospital, Hubei University of Medicine, Shiyan, Hubei, 442000, P. R. China.
BMC cardiovascular disorders
|November 7, 2025
概括
心脏手术后的血糖变化 (GV) 与死亡率的增加有关. 这种标志物可能有助于预测患者的结果与现有的临床因素一起.
科学领域:
- 心脏病学 心脏病学
- 密集护理医学 密集护理医学
- 代谢监测 代谢监测
背景情况:
- 血糖变化 (GV) 可能比绝对葡萄糖水平更好地反映外科手术期间的代谢不稳定性.
- 大型心脏手术后GV的预后意义尚未确立.
研究的目的:
- 为了调查GV与重症监护室 (ICU) 重症心脏手术后患者的死亡风险之间的关联.
- 评估与已确定的临床风险因素相比,GV的预测性能.
主要方法:
- 使用MIMIC-IV数据库对2943名接受冠状动脉旁路移植或门手术的ICU患者进行了回顾性分析.
- GV计算为在ICU停留期间葡萄糖变化系数;主要结局30天死亡率.
- 多变量考克斯回归,IPTW和机器学习模型 (XGBoost) 用于分析和预测.
主要成果:
- 更高的GV独立地与30天,90天和360天死亡率的增加有关.
- 对于最高与最低GV四分位数的危险比率为6.72 (30天),2.46 (90天) 和2.19 (360天).
- 结合GV的XGBoost模型实现了30天死亡率的优异歧视 (AUC0.845),与单独GV的XGBoost模型相比 (AUC0.686).
结论:
- 血糖变异性升高是心脏手术后ICU患者短期和长期死亡率的独立预测因素.
- 经手术后风险分层的GV可以作为一个有价值的补充标记.
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