尼古丁依赖患者与重症监护室狂妄症之间的关联:使用大型临床数据库的回顾性队列研究
Mengqing Yang1, Zhengxin Hu1, Yun Huang1
1Department of Emergency and Critical Care Medicine, ShunDe Hospital of Guangzhou University of Chinese Medicine, No.12, Jinsha Road, Daliang Town, Shunde District, Foshan, Guangdong, 528000, People's Republic of China.
尼古丁依赖显著增加了重症监护室 (ICU) 痴呆症的风险. 早期识别和干预尼古丁依赖对于ICU患者来说至关重要,以减轻妄想风险.
科学领域:
- 关键护理医学 关键护理医学
- 神经科学是一个神经科学.
- 公共卫生 公共卫生
背景情况:
- 尼古丁使用是重症监护室 (ICU) 患者 Delirium 的已知危险因素.
- 关于尼古丁依赖 (ND) 和ICU痴呆症之间的特定关联的证据有限.
研究的目的:
- 调查尼古丁依赖与成年ICU患者 Delirium的发生率之间的联系.
- 为了确定尼古丁依赖是否是ICU Delirium的独立风险因素.
主要方法:
- 使用MIMIC-IV数据库进行的回顾性队列研究 (n=24,043).
- 倾向分数匹配 (PSM) 用于平衡尼古丁依赖和非尼古丁依赖组之间的混因素.
- 考克斯回归和竞争风险模型分析了ND和ICU痴呆发病率之间的关联.
主要成果:
- 尼古丁依赖与ICU Delirium的发生率显著增加 (30.8%与27.2%相比).
- 多变量模型证实了ND是ICU Delirium风险增加的独立风险因素.
- 两组之间没有观察到死亡率或停留时间的显著差异.
结论:
- 尼古丁依赖是ICU中发展的重要危险因素.
- 需要针对性风险评估和干预策略,用于尼古丁依赖患者入院ICU.
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