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在T-LBL/ALL中,BPTF-665aa介导的染色质重塑驱动化学抵抗

Rong-Hui Chen1,2,3,4, Mei Li5, Zhen-Zhong Zhou1,2

  • 1Department of Medical Oncology, Sun Yat-sen University Cancer Center, Guangzhou, P.R. China.

Journal of experimental & clinical cancer research : CR
|November 7, 2025
PubMed
概括

一种新型的循环RNA,circBPTF,通过稳定BPTF蛋白来驱动T细胞淋巴细胞淋巴瘤/白血病 (T-LBL/ALL) 的化学抵抗. 这种蛋白质增强了染色质的可访问性,促进了癌细胞的存活,并提供了一个新的治疗点.

关键词:
在 BPTF-665aa.化学抗药性 化学抗药性是一种抗药性.染色体重塑 染色体重塑 的方法电路BPTFTF 的时间小分子抑制剂小分子抑制剂T-LBL/ALL/所有类型

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