藻类提取物补充剂可以增强通过减弱的PRRSV-1疫苗接种诱导的幽默免疫力
Caroline Hervet1, Frédérick Bussy2, Anne Morvan2
1Oniris, INRAE, BIOEPAR, Nantes, 44300, France.
BMC veterinary research
|November 7, 2025
概括
在猪接种PRRSV疫苗之前,口服海藻提取物补充剂增强了免疫反应,包括增加抗体水平和减少炎症. 这种实用策略显示了提高猪生殖和呼吸系统综合征 (PRRS) 疫苗疗效的前景.
科学领域:
- 动物科学动物科学
- 免疫学 免疫学 免疫学
- 兽医医学 兽医医学 兽医医学
背景情况:
- 猪生殖和呼吸系统综合征 (PRRS) 对全球猪业产生重大影响.
- 目前的活体减弱病毒 (MLV) 疫苗仅对PRRS提供部分保护.
- 需要新的策略来提高疫苗的有效性.
研究的目的:
- 调查口服Ulva衍生海藻提取物补充剂在加强猪对PRRSV-1 MLV疫苗接种的免疫反应方面的疗效.
- 评估两个补充方案:疫苗接种前和疫苗接种后.
主要方法:
- 猪被分为六组,有三个接种疫苗和三个未接种疫苗的对照.
- 两个补充组接受了海藻提取物 (Searup®) 与维生素A和维生素D,无论是接种疫苗前还是接种疫苗后.
- 通过测量血清细胞因子水平,PRRSV病毒载荷和抗PRRSV抗体水平来评估免疫反应.
主要成果:
- 接种疫苗前补充海藻显著增加了疫苗病毒水平,并增强了抗PRRSVIgG抗体反应.
- 这一协议还导致了前期和持续的炎症性细胞因子的减少.
- 接种疫苗后补充剂对病毒载量或幽默反应没有显著影响,病毒持久性仅略有减少.
结论:
- 在接种疫苗之前,用海藻提取物 (Searup®) 作为口服补充剂,显示出在现场条件下改善皮质免疫反应以改善PRRSV疫苗接种的实际策略.
- 这些发现表明藻类提取物和维生素A和维生素D的免疫调节作用.
- 需要进一步的研究来评估对中和抗体,细胞免疫力和对野外菌株的保护的影响.
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