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Updated: Jan 12, 2026

Continuous Fluorescence-Based Endonuclease-Coupled DNA Methylation Assay to Screen for DNA Methyltransferase Inhibitors
06:07

Continuous Fluorescence-Based Endonuclease-Coupled DNA Methylation Assay to Screen for DNA Methyltransferase Inhibitors

Published on: August 5, 2022

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在血液恶性瘤和固体瘤中使用DNA甲基转移酶抑制剂

Valentin Wenger1, Guillermo Garcia-Manero2, Robert Zeiser1,3,4

  • 1Department of Medicine I (Division of Hematology, Oncology and Stem Cell Transplantation), University of Freiburg Medical Center, Faculty of Medicine, Freiburg, Germany.

International journal of cancer
|November 8, 2025
PubMed
概括

DNA甲基转移酶抑制剂 (DNMTi) 在治疗髓状和淋巴状恶性瘤方面表现有前途. 结合疗法,如DNMTi-BCL-2抑制剂,正在探索克服耐药性并改善癌症治疗中的持久反应.

关键词:
不同化的差异化差异化.表观遗传疗法是一种表观遗传疗法.低甲化剂是一种低甲化剂.网红酸是什么意思 网红酸是什么意思维尼托克拉克斯 (Venetoclax) 是一个

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