不协同排便与小肠细菌过度生长有关
John A Damianos1, Ayah Matar1, Houssam Halawi1
1Division of Gastroenterology and Hepatology, Clinical Enteric Neuroscience Translational and Epidemiological Research (C.E.N.T.E.R.), Mayo Clinic, Rochester, Minnesota, USA.
Neurogastroenterology and motility
|November 8, 2025
概括
不协同排便 (DD) 与微生物过度生长 (MO) 有关,包括小肠细菌过度生长 (SIBO) 和肠道甲素过度生长 (IMO). 患有DD的患者显示SIBO和IMO的比率更高,这表明DD可能是MO的危险因素.
科学领域:
- 胃肠病学 胃肠病学
- 微生物学 微生物学
- 生理学 生理学 生理学
背景情况:
- 小肠中的微生物过度生长 (MO),包括小肠细菌过度生长 (SIBO) 和肠子甲素过度生长 (IMO),与胃肠道症状有关,可能是静止的结果.
- 不协同排便 (DD) 是一种与便秘和慢性结肠过渡 (STC) 相关的疾病.
研究的目的:
- 调查异能排便 (DD) 和微生物过度生长 (MO) 之间的关系.
主要方法:
- 对患者进行门测量 (ARM) 和气球驱逐测试 (BET) 进行DD的回顾性分析,以及MO测试 (小肠吸附培养或呼吸测试).
- 使用两个培养值 (≥10^5 CFU/mL和≥10^3 CFU/mL) 来评估SIBO.
- 使用奇平方测试来比较阳性和阴性结果.
主要成果:
- 在≥10^3CFU/mL值时,SIBO在DD患者中比STC患者更为普遍 (85.5%vs64.7%).
- 肠道甲素过度生长 (IMO) 在DD患者中也比STC患者更常见 (p=0.021).
- 患有DD的患者表现出明显更长的BET时间和较低的门放松,无论SIBO或IMO诊断如何.
结论:
- 不协同排便 (DD) 可能成为发展微生物过度生长 (MO) 的危险因素.
- 显著比例的DD患者出现了甲基生成的证据,表明排便障碍和MO之间的联系.
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