3个脂肪指数和5种传染病之间的因果关系:孟德尔的随机化研究
Xiaohong Chen1, Jia Yin1, Chao Chen2
1Department of Emergency, Affiliated Hospital of Southwest Jiaotong University, The Third People's Hospital of Chengdu, Chengdu, Sichuan, China.
Medicine
|November 8, 2025
概括
腰围 (WC) 因果上增加了败血症,胆囊炎和皮肤感染的风险,与身体质量指数 (BMI) 或部周围 (HC) 不同. 控制WC可能会降低感染风险.
科学领域:
- 遗传学 遗传学是一种遗传学.
- 流行病学 流行病学
- 公共卫生 公共卫生
背景情况:
- 关于脂肪和感染风险之间的联系存在不一致的发现.
- 肥胖指数如体重指数 (BMI),腰围 (WC) 和部周长 (HC) 是常用的衡量标准.
- 了解因果关系对于公共卫生干预至关重要.
研究的目的:
- 调查不同脂肪指数 (BMI,WC,HC) 与各种感染风险之间的因果关系.
- 为了确定WC是否比BMI和HC更有效地预测传染病风险,与BMI和HC相比.
主要方法:
- 使用门德尔随机化 (MR) 分析,包括单变量和多变量方法 (MVMR).
- 数据来源于大型生物银行 (英国生物银行,FinnGen) 和联盟.
- 使用反变量加权 (IVW) 和其他MR方法来确保结果的稳定性,并使用Bonferroni对显著性进行校正.
主要成果:
- 多变量MR分析显示,WC与败血症易感性 (OR=1.95),败血症死亡率 (OR=3.23),胆囊炎 (OR=1.87) 和皮肤/皮下组织感染 (SSTI) (OR=1.74) 的风险增加之间存在显著的,独立的因果关系.
- 在BMI或HC和研究的感染之间没有发现显著的因果关系.
- 没有检测到性或反向因果关系的证据.
结论:
- 腰围 (WC) 是几个传染病的重要独立预测因素,包括败血症和胆囊炎.
- 控制WC可能是减少这些感染风险的可行策略.
- 需要进行进一步的前性研究,以探索动态脂肪度测量和跨人群的各种感染.
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