新安健皮通比牙与骨关节炎患者的自我认知之间的关联:一项病例对照研究
Mingyu He1,2, Jian Liu1,2, Guizhen Wang1,2
1Department of Rheumatism Immunity, The First Affiliated Hospital, Anhui University of Chinese Medicine, Hefei, China.
Medicine
|November 8, 2025
概括
骨关节炎 (OA) 患者由于关节疼痛而经历自我感知恶化 (SPP). 新安健皮通比 (XAJPF) 通过恢复脂质和凝血功能来改善SPP,提供潜在的OA治疗.
科学领域:
- 风湿病学和中国传统医学
- 患者报告的慢性疾病管理结果.
背景情况:
- 骨关节炎 (OA) 显著影响患者的自我认知 (SPP),往往与关节疼痛恶化.
- 识别SPP恶化的风险因素对于有效的OA管理至关重要.
- 传统中医 (TCM) 的干预措施,如新安健皮通比 (XAJPF),需要对其对SPP的影响进行调查.
研究的目的:
- 探索与骨关节炎 (OA) 患者自我感知 (SPP) 变化的风险和保护因素.
- 评价新安建皮通比 (XAJPF) 对改善OA患者的SPP的治疗效果.
- 阐明XAJPF通过XAJPF影响SPP的调解机制.
主要方法:
- 一项涉及270名OA患者的病例控制研究.
- 用于风险因素分析的二进制逻辑回归 (Hosmer-Lemeshow测试).
- 自我比较,关联规则分析,引导测试和子组分析,以评估XAJPF有效性和调解因素.
主要成果:
- 导致SPP恶化的危险因素包括生活习惯,晚年,女性性别,体重,炎症升高 (hs-CRP,IL-6),以及脂质/凝血障碍.
- 在OA患者中,XAJPF表现出显著的保护作用和SPP得分的改善.
- 恢复脂质代谢和凝血功能被确定为XAJPF对SPP的影响的关键调解者.
结论:
- 在OA中持续的关节疼痛会对患者的自我感知产生负面影响 (SPP).
- XAJPF在改善OA患者的SPP方面表现有前途,可能通过调节代谢和凝血通路.
- 在OA患者的临床管理中,XAJPF可以被认为是一个有价值的辅助剂,以提高他们的生活质量.
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